IntroductionRadiotherapy and accidental exposure to ionizing radiation cause severe damage to healthy tissue. The gastrointestinal tract is a radiation‐sensitive organ, and gastrointestinal complications of radiation are collectively referred to as gastrointestinal acute radiation syndrome (GI‐ARS). GI‐ARS can cause a clinical problem, called acute radiation enteritis, which involves inflammation, edema, epithelial barrier impairment, ulceration, a decrease in mitotic activity, and crypt defects in the gastrointestinal tract. Bacterial translocation is defined as the passage of viable endogenous bacteria and endotoxins from the gastrointestinal tract to extraintestinal sites such as the mesenteric lymph node (mLN) complex, liver, spleen, kidney, and bloodstream. Endotoxemia and bacteremia are critical events in the pathogenesis of GI‐ARS, and the colon is the primary source of endotoxins, which thus highlights the importance of this tissue's injury during radiation exposure.Goblet cells are columnar epithelial cells specializing in the secretion of high‐molecular‐weight glycoproteins, called mucins, which consist of a protein core, rich in threonine, proline, or serine residues, supplemented with an O‐linked oligosaccharide. These cells play a pivotal role in epithelial defense against luminal stimulants and pathogens. Mucin 2 (MUC2), synthesized by goblet cells, is the predominant structural component of the intestinal mucus layer that functions as a barrier to
Journal of Gastroenterology and Hepatology – Wiley
Published: Jan 1, 2018
Keywords: ; ; ;
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