Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study ( RABAMES ): six‐month results of a prospective randomized clinical trial

Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study ( RABAMES ):... Purpose To compare standard‐of‐care grid laser photocoagulation versus intravitreal ranibizumab (IVR) versus a combination of both in the treatment of chronic (>3 months) macular oedema secondary to branch retinal vein occlusion. Methods Prospective, randomized, multicentre clinical trial. Thirty patients with a best‐corrected visual acuity (BCVA) between 20/320 and 20/40 were randomized 1:1:1 to receive grid laser or three monthly injections of 0.5 mg IVR or both followed by 3 months of observation. Results Mean change from baseline BCVA at month 6 was +2 letters (laser; 0.04 logMAR, 95% confidence interval (−0.17; 0.25)), +17 letters (IVR; 0.34 (0.19; 0.5)) and +6 letters (combination; 0.12 (0.01; 0.24)) (IVR versus laser p = 0.02 and IVR versus combination p = 0.02). At month 3, mean improvement in central retinal thickness (CRT) was 90.6 μm (laser) (−18.65; 199.8), 379.5 μm (IVR) (204.2; −554.8), and 248 μm (167.2; −328.8) (combination) (IVR versus laser p = 0.005, laser versus combination p = 0.02). During the observation period, CRT improved in laser (37.6 μm (−66.82; 142.0)), but deteriorated in IVR (−142.4 μm (−247.6; −37.16)) and combination (−171.7 μm (−250.4; −92.96)) (laser versus IVR p = 0.01, laser versus combination p = 0.002) indicating recurrent oedema. Less laser retreatments (at 8 weeks) were required in combination group (2/10) than grid group (7/10). Conclusion Six‐month results suggest that ranibizumab may be superior to grid laser in improving visual acuity. Grid combined with IVR neither enhanced functional and morphological improvement of IVR nor did it prevent or prolong recurrence of oedema. In IVR groups, CRT increased slowly after stopping injections, whereas improvement in visual acuity was sustained, indicating that morphological changes occur prior to functional impairment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Ophthalmologica Wiley

Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study ( RABAMES ): six‐month results of a prospective randomized clinical trial

Loading next page...
 
/lp/wiley/ranibizumab-for-branch-retinal-vein-occlusion-associated-macular-edema-SA33GOMryn
Publisher
Wiley
Copyright
Copyright © 2015 Acta Ophthalmologica Scandinavica Foundation
ISSN
1755-375X
eISSN
1755-3768
DOI
10.1111/aos.12488
pmid
25042729
Publisher site
See Article on Publisher Site

Abstract

Purpose To compare standard‐of‐care grid laser photocoagulation versus intravitreal ranibizumab (IVR) versus a combination of both in the treatment of chronic (>3 months) macular oedema secondary to branch retinal vein occlusion. Methods Prospective, randomized, multicentre clinical trial. Thirty patients with a best‐corrected visual acuity (BCVA) between 20/320 and 20/40 were randomized 1:1:1 to receive grid laser or three monthly injections of 0.5 mg IVR or both followed by 3 months of observation. Results Mean change from baseline BCVA at month 6 was +2 letters (laser; 0.04 logMAR, 95% confidence interval (−0.17; 0.25)), +17 letters (IVR; 0.34 (0.19; 0.5)) and +6 letters (combination; 0.12 (0.01; 0.24)) (IVR versus laser p = 0.02 and IVR versus combination p = 0.02). At month 3, mean improvement in central retinal thickness (CRT) was 90.6 μm (laser) (−18.65; 199.8), 379.5 μm (IVR) (204.2; −554.8), and 248 μm (167.2; −328.8) (combination) (IVR versus laser p = 0.005, laser versus combination p = 0.02). During the observation period, CRT improved in laser (37.6 μm (−66.82; 142.0)), but deteriorated in IVR (−142.4 μm (−247.6; −37.16)) and combination (−171.7 μm (−250.4; −92.96)) (laser versus IVR p = 0.01, laser versus combination p = 0.002) indicating recurrent oedema. Less laser retreatments (at 8 weeks) were required in combination group (2/10) than grid group (7/10). Conclusion Six‐month results suggest that ranibizumab may be superior to grid laser in improving visual acuity. Grid combined with IVR neither enhanced functional and morphological improvement of IVR nor did it prevent or prolong recurrence of oedema. In IVR groups, CRT increased slowly after stopping injections, whereas improvement in visual acuity was sustained, indicating that morphological changes occur prior to functional impairment.

Journal

Acta OphthalmologicaWiley

Published: Feb 1, 2015

References

  • Levels of VEGF but not VEGF(165b) are increased in the vitreous of patients with retinal vein occlusion
    Ehlken, Ehlken; Rennel, Rennel; Michels, Michels
  • Multiple laser treatments for macular edema attributable to branch retinal vein occlusion
    Esrick, Esrick; Subramanian, Subramanian; Heier, Heier; Devaiah, Devaiah; Topping, Topping; Frederick, Frederick; Morley, Morley
  • Randomized controlled trial of intravitreal ranibizumab versus standard grid laser for macular edema following branch retinal vein occlusion
    Tan, Tan; McAllister, McAllister; Gillies, Gillies; Verma, Verma; Banerjee, Banerjee; Smithies, Smithies; Wong, Wong; Wong, Wong

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off