Quality of life after living donor liver transplant for biliary atresia in Japan

Quality of life after living donor liver transplant for biliary atresia in Japan Liver transplantation (LT) is one of the treatment options to improve survival rate and health‐related quality of life (HRQOL) in pediatric and adolescent patients with end‐stage liver failure. In Japan, biliary atresia (BA) frequently necessitates LT in children and adolescents, with >1,700 pediatric and adolescent patients having undergone LT, most of whom received living donor liver transplantation (LDLT). In Japan, LT for BA achieves good outcomes, and the 5 year survival rate in Japanese patients with BA after LT is approximately 90%.In the assessment of outcomes of LT for pediatric and adolescent BA, objective indexes, such as patient and graft survival rate, are usually used, but patient‐reported outcomes in the Japanese population have not been assessed. Organ transplant aims to cure the primary disease and entails a transition to a new chronic condition. Compared with other diseases, for BA, LT is most often required during infancy, thereby prolonging the number of post‐transplant years. Therefore, in transplantation, patient outcomes cannot be assessed only using objective indexes, and it is important to assess HRQOL outcomes from the perspective of the patient.The HRQOL integrates domains of objective assessments of personal functioning or health status as well as subjective perceptions of health. These http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatrics International Wiley

Quality of life after living donor liver transplant for biliary atresia in Japan

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Japan Pediatric Society
ISSN
1328-8067
eISSN
1442-200X
D.O.I.
10.1111/ped.13442
Publisher site
See Article on Publisher Site

Abstract

Liver transplantation (LT) is one of the treatment options to improve survival rate and health‐related quality of life (HRQOL) in pediatric and adolescent patients with end‐stage liver failure. In Japan, biliary atresia (BA) frequently necessitates LT in children and adolescents, with >1,700 pediatric and adolescent patients having undergone LT, most of whom received living donor liver transplantation (LDLT). In Japan, LT for BA achieves good outcomes, and the 5 year survival rate in Japanese patients with BA after LT is approximately 90%.In the assessment of outcomes of LT for pediatric and adolescent BA, objective indexes, such as patient and graft survival rate, are usually used, but patient‐reported outcomes in the Japanese population have not been assessed. Organ transplant aims to cure the primary disease and entails a transition to a new chronic condition. Compared with other diseases, for BA, LT is most often required during infancy, thereby prolonging the number of post‐transplant years. Therefore, in transplantation, patient outcomes cannot be assessed only using objective indexes, and it is important to assess HRQOL outcomes from the perspective of the patient.The HRQOL integrates domains of objective assessments of personal functioning or health status as well as subjective perceptions of health. These

Journal

Pediatrics InternationalWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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