AbbreviationsASICacid‐sensing ion channelGMQ2‐guanidine‐4‐methylquinazolineIntroductionAcid‐sensing ion channels (ASICs) belong to the degenerin/epithelial Na+ channel superfamily (Kellenberger and Schild, ). The six identified ASIC subunits (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3 and ASIC4) encoded by four genes (ACCN1–ACCN4) (Wemmie et al., ) can form homotrimeric or heterotrimeric cation‐selective ion channels (Benson et al., ; Askwith et al., ; Sherwood et al., ). ASIC1a, ASIC2a, ASIC2b and ASIC4 isoforms are found in the CNS (Akopian et al., ; Alvarez de la Rosa et al., ; Wemmie et al., ), while ASIC3 and ASIC1b isoforms are predominantly expressed in the peripheral nervous system (Chen et al., ; Babinski et al., ). ASICs are implicated in neurotransmission, synaptic plasticity, learning, ischaemia and neuronal cell death and contribute to perception of acid‐mediated inflammatory or post‐operative pain (Wemmie et al., , ; Xiong et al., ; Gao et al., ; Yagi et al., ; Friese et al., ; Deval et al., , ; Yen et al., ).ASIC subunits demonstrate high‐sequence conservation between different mammalian species (rat, mouse and human) and isoforms (rat isoforms show 45–80% sequence similarity). The crystal structure of chicken ASIC1 at 1.9 Å resolution showed that the three‐dimensional architecture of ASIC subunits form trimeric functional complexes.
British Journal of Pharmacology – Wiley
Published: Jan 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.
All for just $49/month
Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.
Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.
It’s easy to organize your research with our built-in tools.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera