Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Kabouridis (2003)
Biological applications of protein transduction technology.Trends in biotechnology, 21 11
P. Wender, D. Mitchell, Kanaka Pattabiraman, E. Pelkey, L. Steinman, J. Rothbard (2000)
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.Proceedings of the National Academy of Sciences of the United States of America, 97 24
P. Järver, Ű. Langel (2004)
The use of cell-penetrating peptides as a tool for gene regulation.Drug discovery today, 9 9
D. Kalderon, B. Roberts, W. Richardson, Alan Smith (1984)
A short amino acid sequence able to specify nuclear locationCell, 39
E. Vivés, C. Granier, P. Prévot, B. Lebleu (2004)
Structure–activity relationship study of the plasma membrane translocating potential of a short peptide from HIV-1 Tat proteinLetters in Peptide Science, 4
J. Fernández‐Carneado, M. Kogan, S. Pujals, E. Giralt (2004)
Amphipathic peptides and drug delivery.Biopolymers, 76 2
J. Gratton, Jun Yu, J. Griffith, R. Babbitt, R. Scotland, Reed Hickey, F. Giordano, W. Sessa (2003)
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivoNature Medicine, 9
P. Thoren, D. Persson, Petter Isakson, M. Goksör, A. Onfelt, B. Nordén (2003)
Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells.Biochemical and biophysical research communications, 307 1
M. Peitz, K. Pfannkuche, K. Rajewsky, F. Edenhofer (2002)
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomesProceedings of the National Academy of Sciences of the United States of America, 99
J. Oehlke, A. Scheller, B. Wiesner, Eberhard Krause, M. Beyermann, Erhard Klauschenz, M. Melzig, M. Bienert (1998)
Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically.Biochimica et biophysica acta, 1414 1-2
E. Gonçalves, E. Kitas, J. Seelig (2005)
Binding of oligoarginine to membrane lipids and heparan sulfate: structural and thermodynamic characterization of a cell-penetrating peptide.Biochemistry, 44 7
Jacek Hawiger (1999)
Noninvasive intracellular delivery of functional peptides and proteins.Current opinion in chemical biology, 3 1
G. Elliott, P. O’Hare (1997)
Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural ProteinCell, 88
Shlomo Nir, J. Nieva (2000)
Interactions of peptides with liposomes: pore formation and fusion.Progress in lipid research, 39 2
P. Thoren, Daniel Persson, M. Karlsson, B. Nordén (2000)
The Antennapedia peptide penetratin translocates across lipid bilayers – the first direct observationFEBS Letters, 482
A. Martin, P. O’Hare, J. McLauchlan, G. Elliott (2002)
Herpes Simplex Virus Tegument Protein VP22 Contains Overlapping Domains for Cytoplasmic Localization, Microtubule Interaction, and Chromatin BindingJournal of Virology, 76
Michael Herbig, U. Fromm, Jeannine Leuenberger, U. Krauss, A. Beck‐Sickinger, H. Merkle (2005)
Bilayer interaction and localization of cell penetrating peptides with model membranes: a comparative study of a human calcitonin (hCT)-derived peptide with pVEC and pAntp(43-58).Biochimica et biophysica acta, 1712 2
K. Sadler, K. Eom, Jin-Long Yang, Yoana Dimitrova, J. Tam (2002)
Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7.Biochemistry, 41 48
Bhawna Gupta, T. Levchenko, V. Torchilin (2005)
Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides.Advanced drug delivery reviews, 57 4
André Ziegler, P. Nervi, M. Dürrenberger, J. Seelig (2005)
The cationic cell-penetrating peptide CPP(TAT) derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence.Biochemistry, 44 1
D. Mitchell, Lawrence Steinman, D. Kim, C. Fathman, J. Rothbard (2000)
Polyarginine enters cells more efficiently than other polycationic homopolymers.The journal of peptide research : official journal of the American Peptide Society, 56 5
S. Cashman, S. Sadowski, D. Morris, J. Frederick, R. Kumar‐Singh (2002)
Intercellular trafficking of adenovirus-delivered HSV VP22 from the retinal pigment epithelium to the photoreceptors--implications for gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy, 6 6
S. Olsnes, O. Klingenberg, A. Wiedlocha (2003)
Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus.Physiological reviews, 83 1
J. Wadia, S. Dowdy (2005)
Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer.Advanced drug delivery reviews, 57 4
Stefanie-Dorothea Krämer, Heidi Wunderli-Allenspach (2003)
No entry for TAT(44-57) into liposomes and intact MDCK cells: novel approach to study membrane permeation of cell-penetrating peptides.Biochimica et biophysica acta, 1609 2
M. Lundberg, M. Johansson (2001)
Is VP22 nuclear homing an artifact?Nature Biotechnology, 19
Gloria Lee, Roland Brandt (1992)
Microtubule-bundling studies revisited: is there a role for MAPs?Trends in cell biology, 2 10
W. Shen, H. Ryser (1978)
Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins.Proceedings of the National Academy of Sciences of the United States of America, 75 4
Satoe Kobayashi, Kenta Takeshima, C. Park, S. Kim, K. Matsuzaki (2000)
Interactions of the novel antimicrobial peptide buforin 2 with lipid bilayers: proline as a translocation promoting factor.Biochemistry, 39 29
D. Lochmann, Edith Jauk, A. Zimmer (2004)
Drug delivery of oligonucleotides by peptides.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 58 2
Simon Jones, Richard Christison, K. Bundell, Catherine Voyce, S. Brockbank, P. Newham, M. Lindsay (2005)
Characterisation of cell‐penetrating peptide‐mediated peptide deliveryBritish Journal of Pharmacology, 145
Ming Zhao, R. Weissleder (2004)
Intracellular cargo delivery using tat peptide and derivativesMedicinal Research Reviews, 24
J. Richard, K. Melikov, E. Vivés, Corinne Ramos, B. Verbeure, M. Gait, L. Chernomordik, B. Lebleu (2003)
Cell-penetrating PeptidesThe Journal of Biological Chemistry, 278
M. Lundberg, M. Johansson (2002)
Positively charged DNA-binding proteins cause apparent cell membrane translocation.Biochemical and biophysical research communications, 291 2
PROPERTIES OF CPPS 13
M. Pooga, M. Hällbrink, M. Zorko, M. Zorko, Ü. Langel (1998)
Cell penetration by transportan.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 12 1
M. Lindsay (2002)
Peptide-mediated cell delivery: application in protein target validation.Current opinion in pharmacology, 2 5
S. Henriques, Júlia Costa, M. Castanho (2005)
Translocation of beta-galactosidase mediated by the cell-penetrating peptide pep-1 into lipid vesicles and human HeLa cells is driven by membrane electrostatic potential.Biochemistry, 44 30
M. Schutze-Redelmeier, H. Gournier, F. Garcia-Pons, M. Moussa, A. Joliot, M. Volovitch, A. Prochiantz, François Lemonnier (1996)
Introduction of exogenous antigens into the MHC class I processing and presentation pathway by Drosophila antennapedia homeodomain primes cytotoxic T cells in vivo.Journal of immunology, 157 2
H. Yoon, Sung Lee, Sung-Woo Cho, J. Lee, C. Yoon, Jinseu Park, T. Kim, Soo‐Young Choi (2002)
TAT-mediated delivery of human glutamate dehydrogenase into PC12 cellsNeurochemistry International, 41
Tomoki Suzuki, S. Futaki, M. Niwa, Seigo Tanaka, K. Ueda, Y. Sugiura (2002)
Possible Existence of Common Internalization Mechanisms among Arginine-rich Peptides*The Journal of Biological Chemistry, 277
J. Maiolo, M. Ferrer, E. Ottinger (2005)
Effects of cargo molecules on the cellular uptake of arginine-rich cell-penetrating peptides.Biochimica et biophysica acta, 1712 2
D. Derossi, A. Joliot, G. Chassaing, A. Prochiantz (1994)
The third helix of the Antennapedia homeodomain translocates through biological membranes.The Journal of biological chemistry, 269 14
G. Drin, S. Cottin, E. Blanc, A. Rees, J. Temsamani (2003)
Studies on the Internalization Mechanism of Cationic Cell-penetrating Peptides*Journal of Biological Chemistry, 278
C. Rousselle, P. Clair, J. Temsamani, J. Scherrmann (2002)
Improved Brain Delivery of Benzylpenicillin with a Peptide-vector-mediated StrategyJournal of Drug Targeting, 10
H. Nagahara, Adamina Vocero-Akbani, E. Snyder, A. Ho, Dawn Latham, N. Lissy, M. Becker-Hapak, S. Ezhevsky, S. Dowdy (1998)
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migrationNature Medicine, 4
P. Thoren, D. Persson, E. Esbjörner, M. Goksör, P. Lincoln, B. Nordén (2004)
Membrane binding and translocation of cell-penetrating peptides.Biochemistry, 43 12
Anna Elmquist, Anna Elmquist, Maria Lindgren, M. Lindgren, Tamas Bartfai, Ü. Langel, Ü. Langel (2001)
VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions.Experimental cell research, 269 2
W. Derer, H. Easwaran, H. Leonhardt, M. Cardoso (2002)
A novel approach to induce cell cycle reentry in terminally differentiated muscle cellsThe FASEB Journal, 16
S. Schwarze, S. Dowdy (2000)
In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA.Trends in pharmacological sciences, 21 2
Z. Mi, J. Mai, Xiaoli Lu, P. Robbins (2000)
Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo.Molecular therapy : the journal of the American Society of Gene Therapy, 2 4
C. Park, Kwan-Su Yi, K. Matsuzaki, Mi Kim, S. Kim (2000)
Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II.Proceedings of the National Academy of Sciences of the United States of America, 97 15
P. Lundberg, Ü. Langel (2003)
A brief introduction to cell‐penetrating peptidesJournal of Molecular Recognition, 16
S. Schwarze, A. Ho, Adamina Vocero-Akbani, S. Dowdy (1999)
In vivo protein transduction: delivery of a biologically active protein into the mouse.Science, 285 5433
G. Elliott, P. O’Hare (2000)
Cytoplasm-to-Nucleus Translocation of a Herpesvirus Tegument Protein during Cell DivisionJournal of Virology, 74
J. Rothbard, Sarah Garlington, Q. Lin, T. Kirschberg, Erik Kreider, P. Mcgrane, P. Wender, P. Khavari (2000)
Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammationNature Medicine, 6
A. Aints, Hayrettin Guven, Gösta Gahrton, C. Smith, M. Dilber (2001)
Mapping of herpes simplex virus-1 VP22 functional domains for inter- and subcellular protein targetingGene Therapy, 8
K. Ford, D. Darling, B. Souberbielle, F. Farzaneh (2001)
Protein transduction: a new tool for the study of cellular ageing and senescenceMechanisms of Ageing and Development, 121
E. Vivès, P. Brodin, B. Lebleu (1997)
A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus*The Journal of Biological Chemistry, 272
Christina Foerg, U. Ziegler, J. Fernández‐Carneado, E. Giralt, R. Rennert, A. Beck‐Sickinger, H. Merkle (2005)
Decoding the entry of two novel cell-penetrating peptides in HeLa cells: lipid raft-mediated endocytosis and endosomal escape.Biochemistry, 44 1
Pille Säälik, Anna Elmquist, Mats Hansen, K. Padari, K. Saar, Kaido Viht, Ű. Langel, M. Pooga (2004)
Protein cargo delivery properties of cell-penetrating peptides. A comparative study.Bioconjugate chemistry, 15 6
M. Hällbrink, A. Florén, A. Florén, Anna Elmquist, Anna Elmquist, M. Pooga, Tamas Bartfai, Ü. Langel, Ü. Langel (2001)
Cargo delivery kinetics of cell-penetrating peptides.Biochimica et biophysica acta, 1515 2
M. Zorko, Ű. Langel (2005)
Cell-penetrating peptides: mechanism and kinetics of cargo delivery.Advanced drug delivery reviews, 57 4
S. Schwarze, K. Hruska, S. Dowdy (2000)
Protein transduction: unrestricted delivery into all cells?Trends in cell biology, 10 7
M. Pooga, M. Lindgren, M. Hällbrink, E. Brakenhielm, Ü. Langel (1998)
Galanin‐Based Peptides, Galparan and Transportan, with Receptor‐Dependent and Independent ActivitiesAnnals of the New York Academy of Sciences, 863
(2001)
Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery
A. Phelan, G. Elliott, P. O’Hare (1998)
Intercellular delivery of functional p53 by the herpesvirus protein VP22Nature Biotechnology, 16
J. Temsamani, P. Vidal (2004)
The use of cell-penetrating peptides for drug delivery.Drug discovery today, 9 23
D. Derossi, G. Chassaing, A. Prochiantz (1998)
Trojan peptides: the penetratin system for intracellular delivery.Trends in cell biology, 8 2
A. Frankel, C. Pabo (1988)
Cellular uptake of the tat protein from human immunodeficiency virusCell, 55
May Morris, Laurent Chaloin, Frédéric Heitz, G. Divita (2000)
Translocating peptides and proteins and their use for gene delivery.Current opinion in biotechnology, 11 5
Nicolas Caron, Yvan Torrente, Yvan Torrente, Geoffrey Camirand, Mathieu Bujold, Pierre Chapdelaine, Karine Leriche, N. Bresolin, Jacques Tremblay (2001)
Intracellular delivery of a Tat-eGFP fusion protein into muscle cells.Molecular therapy : the journal of the American Society of Gene Therapy, 3 3
M. Chellaiah, Norihito Soga, S. Swanson, Sandy McAllister, U. Alvarez, Dongmei Wang, S. Dowdy, K. Hruska (2000)
Rho-A Is Critical for Osteoclast Podosome Organization, Motility, and Bone Resorption*The Journal of Biological Chemistry, 275
S. Futaki (2002)
Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms.International journal of pharmaceutics, 245 1-2
S. Fawell, J. Seery, Y. Daikh, C. Moore, C. Ling, Pepinsky Blake, J. Barsoum (1994)
Tat-mediated delivery of heterologous proteins into cells.Proceedings of the National Academy of Sciences of the United States of America, 91
M. Green, P. Loewenstein (1988)
Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator proteinCell, 55
A. Kerkis, I. Kerkis, G. Rádis-Baptista, E. Oliveira, A. Vianna-Morgante, L. Pereira, T. Yamane (2004)
Crotamine is a novel cell‐penetrating protein from the venom of rattlesnake Crotalus durissus terrificusThe FASEB Journal, 18
R. Fischer, Karsten Köhler, M. Fotin‐Mleczek, R. Brock (2004)
A Stepwise Dissection of the Intracellular Fate of Cationic Cell-penetrating Peptides*Journal of Biological Chemistry, 279
Different approaches have been developed for the introduction of macromolecules, proteins and DNA into target cells. Viral (retroviruses, lentiviruses, etc.) and nonviral (liposomes, bioballistics etc.) vectors as well as lipid particles have been tested as DNA delivery systems. However, all of them share several undesirable effects that are difficult to overcome, such as unwanted immunoresponse and limited cell targeting. The discovery of the cell penetrating peptides (CPPs) showing properties of macromolecules carriers and enhancers of viral vectors, opened new opportunities for the delivery of biologically active cargos, including therapeutically relevant genes into various cells and tissues. This review summarizes recent data about the best characterized CPPs as well as those sharing cell‐penetrating and cargo delivery properties despite differing in the primary sequence. The putative mechanisms of CPPs penetration into cells and interaction with intracellular structures such as chromosomes, cytoskeleton and centrioles are addressed. We further discuss recent developments in overcoming the lack of cells specificity, one of the main obstacles for CPPs application in gene therapy. In particular, we review a newly discovered affinity of CPPs to actively proliferating cells. IUBMB Life, 58: 7 ‐ 13, 2006
IUBMB Life – Wiley
Published: Jan 1, 2006
Keywords: Cell penetrating peptides; DNA delivery systems
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.