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The percentage of cells in S‐phase (S‐index) was calculated from DNA histograms of 453 primary and metastatic human solid tumors (predominantly bladder, breast, colorectal, renal, prostate, ovarian and lung carcinomas, melanomas, and sarcomas). S‐indices varied widely among both primary and metastatic tumors (1–48%); there was no significant difference in S‐indices between primary and metastatic tumors. The S‐indices for aneuploid tumors were signifycantly higher than for diploid tumors. When data for all aneuploid tumors were analyzed collectively, there was no significant relationship between S‐index and DNA ploidy index. However, for colorectal and ovarian carcinomas S‐indices increased, and for lung carcinomas S‐indices decreased with elevation in the degree of DNA ploidy. Lung carcinomas had the highest S‐indices. Comparison of flow cytometry (FCM) and cytology data indicated that for most diploid tumors S‐indices reflect the proportion of S‐phase cells among a mixed population of normal and tumor cells. For most aneuploid tumors, the proportion of tumor cells estimated cytologically was similar to the proportion of aneuploid cells estimated by FCM. For a small proportion of aneuploid tumors a comparison of cytology and FCM data indicated the presence of a predominant diploid tumor stemline and a minor stemline with aneuploid DNA content. There was a wide spread in the values of S‐indices within tumor groups defined by degree of differentiation and stage of disease at surgery.
Cytometry Part A – Wiley
Published: Nov 1, 1984
Keywords: ; ;
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