INTRODUCTIONImage‐based tumor volumetry uses a summation of 2D tumor areas delineated slice by slice in order to approximate the true tumor volume. In head and neck squamous cell carcinoma (HNSCC), tumor volume may correlate better with treatment outcome than conventional tumor staging. Interestingly, tumor volume data from patients with HNSCC with primary surgical treatment is sparse. A likely reason for this is that tumor volumes are routinely calculated during radiotherapy (RT) planning but not before surgery. However, for patients treated with primary RT or primary concurrent radiochemotherapy, tumor volume was a powerful predictor of recurrence and overall survival (OS). Knegjens and colleagues retrospectively measured tumor volume in 360 selected patients with advanced HNSCC treated with radiochemotherapy. The hazard for recurrence increased by 14% per 10 mL of additional tumor volume. The authors did not observe a comparable relation for T classification and concluded that tumor volume predicts recurrence more reliably than T classification in this specific setting. Similar observations have recently been reported for RT alone by Rutkowski in a literature review. A better correlation of tumor volume with treatment outcome compared to conventional T classification was observed by Strongin and co‐authors. They retrospectively evaluated 78 patients with advanced nonnasopharyngeal
Head & Neck: Journal for the Sciences & Specialties of the Head and Neck – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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