INTRODUCTIONOral squamous cell carcinoma (OSCC) is one of the most common cancers. However, despite surgery with or without combined chemoradiotherapy, the 5‐year survival rate and recurrence rate remain poor (Wang et al., ; Xu, Wang, Yuan, Feng, & Han, ). Thus, many studies have focused on prognostic factors and their reliability for use with OSCC, such as clinical stage, histological signs, and pathologic grade (Meng et al., ; Montes et al., ; Morris, Patel, Shah, & Ganly, ; Philip & James, ; Sagheb, Sagheb, Taylor, Al‐Nawas, & Walter, ; Valentini et al., ; Yang et al., ). Among these factors, the prognostic value of pathologic grade is attracting increasing interest, but not without controversy.In most researches, the pathologic grade was estimated by the histopathological grading system proposed by the World Health Organization (WHO) (Amin et al., ; Barnes, Eveson, Reichart, & Sidransky, ; Broders, ). In this study, the pathologic grade was also evaluated by this method. However, the conventional classification is suggested by many authors that it cannot predict the prognosis of OSCC independently; furthermore, similar results were observed in our previous studies (Feng et al., ; Niu et al., ). Therefore, new methods about pathologic grade were recently proposed, and studies regarding the feasibility of
Oral Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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