Prognostic models for RPS patients—Attempting to predict patient outcomes

Prognostic models for RPS patients—Attempting to predict patient outcomes INTRODUCTIONPrognosis prediction in RPS patientsRetroperitoneal sarcomas (RPS) are a heterogeneous group of tumors with a wide prognostic range. Contrary to other sarcoma sites such as the extremities where outcome is primarily limited by distant failure, local control is the central challenge in RPS patients. The main tumor‐related prognostic factors in RPS have historically been pathologic grade, size, histologic subtype, and multifocality. Also patient characteristics such as age at presentation and treatment variables such as completeness of resection, tumor rupture, and center expertise exert a strong influence on patient prognosis. The relative contribution of each prognostic factor on the oncological outcome is different and only considering the simultaneous effect of the combination of each variable can the physician attempt to define the clinical course of retroperitoneal sarcoma.Although the 10‐year overall survival (OS) of primary resected RPS patients is about 46% the natural history of these tumors varies widely according to the histological subtype. Specifically, more favorable histologies include well‐differentiated liposarcoma (WDLPS) and solitary fibrous tumor (SFT), as the 7‐year OS is greater than 80% in these subtypes. SFT are generally cured with adequate surgical resection, although a minority (less than 10%), have more aggressive behavior with metastatic potential. WDLPS in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Prognostic models for RPS patients—Attempting to predict patient outcomes

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24903
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONPrognosis prediction in RPS patientsRetroperitoneal sarcomas (RPS) are a heterogeneous group of tumors with a wide prognostic range. Contrary to other sarcoma sites such as the extremities where outcome is primarily limited by distant failure, local control is the central challenge in RPS patients. The main tumor‐related prognostic factors in RPS have historically been pathologic grade, size, histologic subtype, and multifocality. Also patient characteristics such as age at presentation and treatment variables such as completeness of resection, tumor rupture, and center expertise exert a strong influence on patient prognosis. The relative contribution of each prognostic factor on the oncological outcome is different and only considering the simultaneous effect of the combination of each variable can the physician attempt to define the clinical course of retroperitoneal sarcoma.Although the 10‐year overall survival (OS) of primary resected RPS patients is about 46% the natural history of these tumors varies widely according to the histological subtype. Specifically, more favorable histologies include well‐differentiated liposarcoma (WDLPS) and solitary fibrous tumor (SFT), as the 7‐year OS is greater than 80% in these subtypes. SFT are generally cured with adequate surgical resection, although a minority (less than 10%), have more aggressive behavior with metastatic potential. WDLPS in

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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