Prognostic markers in congenital diaphragmatic hernia: Left ventricular diameter and pulmonary hypertension

Prognostic markers in congenital diaphragmatic hernia: Left ventricular diameter and pulmonary... Despite improvements in intensive care support, congenital diaphragmatic hernia (CDH) is still a life‐threatening anomaly. The prevalence of the disease is 1:2,000–1:3,000 live births and the mortality rate is high (30–40%). Although many factors play role in the prognosis of CDH, the major determinant of survival is pulmonary hypoplasia and related pulmonary hypertension (PH).Displacement of abdominal organs to the thoracic cavity due to the diaphragm defect causes pulmonary hypoplasia and abnormality in pulmonary vascular structure by affecting lung development in the intrauterine period. The degree of PH as a result of abnormal heart and lung development determines the severity and prognosis of CDH. Progressive increase in pulmonary artery pressure (PAP), right ventricular (RV) failure and concomitant left ventricular (LV) dysfunction are associated with mortality in PH. The degree of PH and persistent PH (PPH) can be determined on conventional echocardiography. There are limited studies on the echocardiographic prognostic indices of CDH in infants. The aim of this study was therefore to investigate whether LV diameter and non‐invasive predicted PAP could be used to predict outcome in CDH.MethodsThis retrospective study was performed in January 2012–December 2016 in patients with CDH. The exclusion criteria were birth before 36 weeks of gestation, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatrics International Wiley

Prognostic markers in congenital diaphragmatic hernia: Left ventricular diameter and pulmonary hypertension

Loading next page...
 
/lp/wiley/prognostic-markers-in-congenital-diaphragmatic-hernia-left-ventricular-biMYi5etBR
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Japan Pediatric Society
ISSN
1328-8067
eISSN
1442-200X
D.O.I.
10.1111/ped.13464
Publisher site
See Article on Publisher Site

Abstract

Despite improvements in intensive care support, congenital diaphragmatic hernia (CDH) is still a life‐threatening anomaly. The prevalence of the disease is 1:2,000–1:3,000 live births and the mortality rate is high (30–40%). Although many factors play role in the prognosis of CDH, the major determinant of survival is pulmonary hypoplasia and related pulmonary hypertension (PH).Displacement of abdominal organs to the thoracic cavity due to the diaphragm defect causes pulmonary hypoplasia and abnormality in pulmonary vascular structure by affecting lung development in the intrauterine period. The degree of PH as a result of abnormal heart and lung development determines the severity and prognosis of CDH. Progressive increase in pulmonary artery pressure (PAP), right ventricular (RV) failure and concomitant left ventricular (LV) dysfunction are associated with mortality in PH. The degree of PH and persistent PH (PPH) can be determined on conventional echocardiography. There are limited studies on the echocardiographic prognostic indices of CDH in infants. The aim of this study was therefore to investigate whether LV diameter and non‐invasive predicted PAP could be used to predict outcome in CDH.MethodsThis retrospective study was performed in January 2012–December 2016 in patients with CDH. The exclusion criteria were birth before 36 weeks of gestation,

Journal

Pediatrics InternationalWiley

Published: Jan 1, 2018

Keywords: ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from Google Scholar, PubMed
Create lists to organize your research
Export lists, citations
Access to DeepDyve database
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off