Correspondence Clinical Letter erythrocytes. These channels were lined by neoplastic cells Clinical Letter that were negative for endothelial markers D2-40 and CD- 31. Further immunohistochemical staining showed consis- tent positivity for melanocytic markers (S-100, SOX-9, and HMB-45) and negativity for cytokeratins A1–A3 (Figure 2). Given the clinical and histological findings, a diagnosis DOI: 10.1111/ddg.13437 of primary angiomatoid melanoma (Clark level III, Bres- low thickness 5.2 mm, with evidence of ulceration between Dear Editors, 3–5 mm) was established. Whole-body positron emission to- mography-computed tomography (PET-CT) was performed, A 63-year-old woman with no relevant medical history revealing metastatic disease in the lungs, liver, and celiac presented to our hospital with changes in the morphology lymph nodes. Genetic testing for both V600E and V600K and color of a chronic cutaneous lesion. Two weeks prior mutations of the BRAF gene was performed using real-time to consultation, the lesion had bled profusely, subsequently PCR (THxID-BRAF AMP, bioMérieux, France), revealing decreasing significantly in size. Dermatological examination a V600E mutation. Following the diagnosis, the patient was revealed a purplish tumor (1.5 cm in diameter) in the right referred to the oncology department and started on vemura- scapular region, arising from a slightly raised brown papule. fenib
Journal Der Deutschen Dermatologischen Gesellschaft – Wiley
Published: Jan 1, 2018
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