Fever without source (FWS) in neonates–young infants up to 3 months of age is a potentially life‐threatening illness because the risk of severe bacterial infection (SBI) at this age is higher than that in older children. Today, the epidemiology of FWS during early infancy has changed because of intrapartum antibiotic prophylaxis for group B streptococcus and the introduction of Haemophilus influenzae type b and pneumococcal vaccination. During the past decade, detection of various viruses has improved by virtue of the development of new molecular techniques and the availability of monoclonal antibodies for many viral species. Furthermore, the FWS etiology during early infancy is being gradually elucidated.Human parechovirus (HPeV) and human non‐polio enterovirus (EV) are important causes of viral infection and meningitis in neonates and young infants. The clinical spectrum of HPeV and EV infections varies from fever to severe systemic disease, including sepsis and meningoencephalitis, which might engender severe neuropsychological sequelae. Several studies have specifically examined HPeV and EV prevalence in European countries and the USA, but their prevalence and clinical characteristics remain largely unknown in Asian countries.This study was conducted to investigate the prevalence of HPeV‐ and EV‐associated infection in a cohort of unselected pediatric patients aged <3 months old
Pediatrics International – Wiley
Published: Jan 1, 2018
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