INTRODUCTIONAsthma and allergy are major public health issues worldwide. As immune and lung development occur largely in utero and during early childhood, developmental programming by pre‐ and post‐natal changing lifestyle and environmental influences acting during this critical period of life is a plausible pathway for respiratory diseases and allergy upsurge over the past few decades.Globally, it is estimated that a billion people may suffer from vitamin D deficiency or insufficiency, including pregnant women who are especially at high risk. Vitamin D status, which is assessed by circulating 25(OH)D levels, is easily modified by sun exposure or diet and therefore makes it an attractive target biomarker for monitoring and prevention. Given the presence of vitamin D receptors on immune cells and the airways, and its multiple effects on the developing lung and immune system, immunomodulation, and regulation of inflammation, vitamin D has gained much interest in recent years as a key modifiable risk factor of asthma and allergy in childhood.To date, two randomized controlled trials (RCTs) have examined the impact of vitamin D supplementation during pregnancy in relation to wheezing and asthma in the offspring showing inconclusive results. Chawes et al showed that supplementation with 2800 IU/d of vitamin D3 during the
Pediatric Allergy and Immunology – Wiley
Published: Jan 1, 2018
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