Predictive value of neutrophil to lymphocyte ratio in long‐term outcomes of left main and/or three‐vessel disease in patients with acute myocardial infarction

Predictive value of neutrophil to lymphocyte ratio in long‐term outcomes of left main and/or... INTRODUCTIONAtherosclerotic coronary artery disease (CAD) is a complex and chronic inflammatory disease. Patients with left main disease (LMD) and/or three‐vessel coronary disease (3VD) are at the highest risk for cardiovascular adverse events in CAD . Previous studies have reported various clinical and anatomical scores, including SYNTAX score, residual SYNTAX score, and SYNTAX score II, that are useful for stratifying high‐risk patients. However, it is difficult to easily apply them in clinical settings because of complexity. Notably, it is essential to find readily available clinical or laboratory markers that predicate future clinical outcomes in LMD/3VD. Acute myocardial infarction (AMI) induces acute inflammatory and stress responses that are characterized by increased mobilization of leukocytes in the necrotic area .Circulating white blood cell (WBC) counts have been established as a marker of inflammation, and previous studies have reported that the WBC count recorded within 24 hr of admission to hospital is a strong and independent predictor of mortality and major adverse events for AMI patients . Neutrophilia reflects the systemic inflammatory status. Similarly, a low lymphocyte count is significantly and independently associated with increased cardiovascular morbidity and mortality .Recently, the circulating neutrophil to lymphocyte ratio (NLR) has emerged as a potent composite http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Catheterization and Cardiovascular Interventions Wiley

Predictive value of neutrophil to lymphocyte ratio in long‐term outcomes of left main and/or three‐vessel disease in patients with acute myocardial infarction

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1522-1946
eISSN
1522-726X
D.O.I.
10.1002/ccd.27495
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONAtherosclerotic coronary artery disease (CAD) is a complex and chronic inflammatory disease. Patients with left main disease (LMD) and/or three‐vessel coronary disease (3VD) are at the highest risk for cardiovascular adverse events in CAD . Previous studies have reported various clinical and anatomical scores, including SYNTAX score, residual SYNTAX score, and SYNTAX score II, that are useful for stratifying high‐risk patients. However, it is difficult to easily apply them in clinical settings because of complexity. Notably, it is essential to find readily available clinical or laboratory markers that predicate future clinical outcomes in LMD/3VD. Acute myocardial infarction (AMI) induces acute inflammatory and stress responses that are characterized by increased mobilization of leukocytes in the necrotic area .Circulating white blood cell (WBC) counts have been established as a marker of inflammation, and previous studies have reported that the WBC count recorded within 24 hr of admission to hospital is a strong and independent predictor of mortality and major adverse events for AMI patients . Neutrophilia reflects the systemic inflammatory status. Similarly, a low lymphocyte count is significantly and independently associated with increased cardiovascular morbidity and mortality .Recently, the circulating neutrophil to lymphocyte ratio (NLR) has emerged as a potent composite

Journal

Catheterization and Cardiovascular InterventionsWiley

Published: Jan 15, 2018

Keywords: ; ; ;

References

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