Abbreviations3Dthree‐dimensionalBWbirthweightCTAcomputed tomography angiographyFGRfetal growth restrictionGAgestational agePVMplacental vascular malperfusionKey MessagePlacental computed tomography angiography provides new insights into the fetoplacental macrovasculature. In normal pregnancy, macrovascular volume increases by vessel branching rather than vessel elongation. The fetal growth restriction placenta is smaller; however, the macrovascular volume is maintained because of an increased vascular density.IntroductionPlacental dysfunction leading to fetal growth restriction (FGR) complicates 3% of all pregnancies and is associated with adverse neonatal outcomes . The underlying cause of placental dysfunction is not completely understood, but maternal malperfusion leading to placental hypoxia and subsequent abnormal development of the fetoplacental vasculature is a possible etiology .The human fetoplacental vasculature consists of the conductive part: chorionic vessels, stem villi vessels, intermediate villi vessels; and the functional unit: the terminal villi capillaries. Current knowledge on the fetoplacental vasculature in FGR pregnancies predominantly focuses on the microvasculature including the intermediate and terminal villi vessels. Several studies report a hypovascularized microvasculature of the FGR placenta with reduced vascular volume and surface area of the terminal villi capillaries due to fewer vessel branches and vessel elongation . In contrast, the fetoplacental macrovasculature, considered as the chorionic vessels and stem villi vessels, is only sparsely described. In the FGR placenta,
Acta Obstetricia Et Gynecologica Scandinavica – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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