Post‐operative surveillance in retroperitoneal soft tissue sarcoma: The importance of tumor histology in guiding strategy

Post‐operative surveillance in retroperitoneal soft tissue sarcoma: The importance of tumor... INTRODUCTIONThe cornerstone of therapy for many solid organ malignancies is curative‐intent surgical resection, but unfortunately, a significant proportion of patients will develop local and/or distant recurrences at some point in the course of their disease. As a result, post‐operative surveillance is an important component of the coordinated care of the cancer patient. There are several diagnostic tools available to clinicians to survey patients after curative‐intent resection, including: (i) history and physical examination; (ii) laboratory biomarkers; and (iii) cross‐sectional and functional imaging. Although cost‐effective strategies in support of routine surveillance are debatable, the goal of post‐operative surveillance is to detect recurrent disease at an early stage that would allow such disease to be effectively treated with either locoregional or systemic therapies. The goal of these interventions is to eradicate or establish control of disease with the ultimate purpose of prolonging survival or providing a framework for effective palliative care prior to the development of advanced disease.Numerous malignancies, such as lung, gastroesophageal, and colorectal cancers, have well‐established post‐operative surveillance recommendations to guide the clinician and facilitate an early diagnosis of tumor recurrence. The challenge in developing such guidelines however lies in the diversity of the tumor biology and behavior of these http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Post‐operative surveillance in retroperitoneal soft tissue sarcoma: The importance of tumor histology in guiding strategy

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Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24927
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONThe cornerstone of therapy for many solid organ malignancies is curative‐intent surgical resection, but unfortunately, a significant proportion of patients will develop local and/or distant recurrences at some point in the course of their disease. As a result, post‐operative surveillance is an important component of the coordinated care of the cancer patient. There are several diagnostic tools available to clinicians to survey patients after curative‐intent resection, including: (i) history and physical examination; (ii) laboratory biomarkers; and (iii) cross‐sectional and functional imaging. Although cost‐effective strategies in support of routine surveillance are debatable, the goal of post‐operative surveillance is to detect recurrent disease at an early stage that would allow such disease to be effectively treated with either locoregional or systemic therapies. The goal of these interventions is to eradicate or establish control of disease with the ultimate purpose of prolonging survival or providing a framework for effective palliative care prior to the development of advanced disease.Numerous malignancies, such as lung, gastroesophageal, and colorectal cancers, have well‐established post‐operative surveillance recommendations to guide the clinician and facilitate an early diagnosis of tumor recurrence. The challenge in developing such guidelines however lies in the diversity of the tumor biology and behavior of these

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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