Possible transmission of parvovirus B19 from intravenous immune globulin

Possible transmission of parvovirus B19 from intravenous immune globulin To look for genetic changes in human parvovirus B19 that might be associated with chronic infection, we sequenced B19 DNA obtained from serum specimens collected over an approximately 1‐year period from a patient with systemic vasculitis. A comparison of the nucleotide sequences of the VP1/VP2 gene from four specimens revealed an abrupt change in the B19 genotype that coincided with initiation of intravenous immune globulin (IVIG) therapy. We suspect that one or more of the lots of IVIG administered to the patient were contaminated with B19. If true, this finding suggests that investigators must be careful in linking B19 infection to disease based on detection of B19 DNA in persons who have received multiple unit blood products. J. Med. Virol. 53:233–236, 1997. Published 1997 Wiley‐Liss, Inc. This article was prepared by a group consisting of both United States government employees and non‐United States government employees, and as such is subject to 17 U.S.C. Sec. 105. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Possible transmission of parvovirus B19 from intravenous immune globulin

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Publisher
Wiley
Copyright
Published 1997 Wiley‐Liss, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/(SICI)1096-9071(199711)53:3<233::AID-JMV9>3.0.CO;2-9
Publisher site
See Article on Publisher Site

Abstract

To look for genetic changes in human parvovirus B19 that might be associated with chronic infection, we sequenced B19 DNA obtained from serum specimens collected over an approximately 1‐year period from a patient with systemic vasculitis. A comparison of the nucleotide sequences of the VP1/VP2 gene from four specimens revealed an abrupt change in the B19 genotype that coincided with initiation of intravenous immune globulin (IVIG) therapy. We suspect that one or more of the lots of IVIG administered to the patient were contaminated with B19. If true, this finding suggests that investigators must be careful in linking B19 infection to disease based on detection of B19 DNA in persons who have received multiple unit blood products. J. Med. Virol. 53:233–236, 1997. Published 1997 Wiley‐Liss, Inc. This article was prepared by a group consisting of both United States government employees and non‐United States government employees, and as such is subject to 17 U.S.C. Sec. 105.

Journal

Journal of Medical VirologyWiley

Published: Nov 1, 1997

References

  • Blood donor screening for parvovirus B19
    Cohen, Cohen; Field, Field; Gudnadottir, Gudnadottir; Beard, Beard; Barbara, Barbara
  • Hypoplastic anemia in a hemophiliac first infused with a solvent/detergent treated factor VIII concentrate: The role of human B19 parvovirus
    Morfini, Morfini; Longo, Longo; Ferrini, Ferrini; Azzi, Azzi; Zakrewska, Zakrewska; Ciappi, Ciappi; Kolumban, Kolumban
  • Partial nucleotide sequencing and characterization of human parvovirus B19 genome DNAs from damaged human fetuses and from patients with leukemia
    Umene, Umene; Nunoue, Nunoue

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