Platelet‐predominate gene expression and reticulated platelets in nonvalvular atrial fibrillation: Effect of pulmonary veins isolation

Platelet‐predominate gene expression and reticulated platelets in nonvalvular atrial... 1INTRODUCTIONPlatelets are enucleated megakaryocytic cell fragments released under the shear stress. The sequence of genesis begins with promotion of cytoplasmic elongation acting through microtubular architecture resulting in proplatelet formation and release from the megakaryocyte. Proplatelets evolve to reticulated platelets (RPs) when released from the bone marrow. RPs are characterized by an abundance of megakaryocyte‐derived RNA, proteins, and molecular machinery necessary for translation. These RPs can be distinguished from other platelets by selective binding to thiazole orange dye (TO), which stains ribonucleic acid and enhances its fluorescence signal.Whereby RPs are felt to represent young newly formed platelets analogous to the erythroid reticulocyte, their proportion may represent an indicator or index of platelet turnover in the circulation. There are several clinical entities that support this concept, including immune thrombocytopenic purpura and essential thrombocythemia. With bone marrow failure and chemotherapy, RP content falls. An elevation of RP precedes platelet count recovery after chemotherapy or with growth factor therapy.Beyond morphologic distinction, RP may be more active and more prone to thrombus participation relative to their older counterparts. High RP content has also been reported in several thrombotic conditions such as ischemic stroke, ischemic heart disease, and particularly acute coronary syndromes. In these conditions, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cardiovascular Electrophysiology Wiley

Platelet‐predominate gene expression and reticulated platelets in nonvalvular atrial fibrillation: Effect of pulmonary veins isolation

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Publisher
Wiley
Copyright
Journal compilation © 2018 Wiley Periodicals, Inc.
ISSN
1045-3873
eISSN
1540-8167
D.O.I.
10.1111/jce.13438
Publisher site
See Article on Publisher Site

Abstract

1INTRODUCTIONPlatelets are enucleated megakaryocytic cell fragments released under the shear stress. The sequence of genesis begins with promotion of cytoplasmic elongation acting through microtubular architecture resulting in proplatelet formation and release from the megakaryocyte. Proplatelets evolve to reticulated platelets (RPs) when released from the bone marrow. RPs are characterized by an abundance of megakaryocyte‐derived RNA, proteins, and molecular machinery necessary for translation. These RPs can be distinguished from other platelets by selective binding to thiazole orange dye (TO), which stains ribonucleic acid and enhances its fluorescence signal.Whereby RPs are felt to represent young newly formed platelets analogous to the erythroid reticulocyte, their proportion may represent an indicator or index of platelet turnover in the circulation. There are several clinical entities that support this concept, including immune thrombocytopenic purpura and essential thrombocythemia. With bone marrow failure and chemotherapy, RP content falls. An elevation of RP precedes platelet count recovery after chemotherapy or with growth factor therapy.Beyond morphologic distinction, RP may be more active and more prone to thrombus participation relative to their older counterparts. High RP content has also been reported in several thrombotic conditions such as ischemic stroke, ischemic heart disease, and particularly acute coronary syndromes. In these conditions,

Journal

Journal of Cardiovascular ElectrophysiologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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