Plasma polymerized C:H:N:O thin films for controlled release of antibiotic substances

Plasma polymerized C:H:N:O thin films for controlled release of antibiotic substances INTRODUCTIONDevelopment of materials that enable temporal or spatial control of drug delivery represents one of the most rapidly advancing areas of current research, because of their numerous advantages compared to conventional dosage forms (e.g., improved efficacy and reduced toxicity).A typical example of drug delivery systems are antibacterial surfaces which can prevent the development of biofilms and post‐surgery bacterial infections that represents one the most serious problems in implant surgery. The onset of such infections may be connected either with contaminated surfaces of the implants or with biofilms of planktonic bacteria formed on it. It was found that Staphylococcus epidermidis and Staphylococcus aureus bacteria are the most frequent source of reported infections. These biofilms are usually dangerous for the patient, because of their resistance. Hence, development of surfaces with gradually released antibacterial agents that stop biofilm formation represents a promising strategy. The main advantage of this approach is based on a local effect as opposed to the oral and/or infusion treatment with conventional dosage of antibiotics with its potential multiple side effects on the patient body.There already exist several methods working on such principle. Some of them are based on a release of metal ions like Ag+ and Cu+ which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Plasma Processes and Polymers Wiley

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
1612-8850
eISSN
1612-8869
D.O.I.
10.1002/ppap.201700160
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONDevelopment of materials that enable temporal or spatial control of drug delivery represents one of the most rapidly advancing areas of current research, because of their numerous advantages compared to conventional dosage forms (e.g., improved efficacy and reduced toxicity).A typical example of drug delivery systems are antibacterial surfaces which can prevent the development of biofilms and post‐surgery bacterial infections that represents one the most serious problems in implant surgery. The onset of such infections may be connected either with contaminated surfaces of the implants or with biofilms of planktonic bacteria formed on it. It was found that Staphylococcus epidermidis and Staphylococcus aureus bacteria are the most frequent source of reported infections. These biofilms are usually dangerous for the patient, because of their resistance. Hence, development of surfaces with gradually released antibacterial agents that stop biofilm formation represents a promising strategy. The main advantage of this approach is based on a local effect as opposed to the oral and/or infusion treatment with conventional dosage of antibiotics with its potential multiple side effects on the patient body.There already exist several methods working on such principle. Some of them are based on a release of metal ions like Ag+ and Cu+ which

Journal

Plasma Processes and PolymersWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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