Plasma endotoxin levels in horses subjected to carbohydrate induced laminitis

Plasma endotoxin levels in horses subjected to carbohydrate induced laminitis Summary Thirteen (65 per cent) of 20 horses subjected to carbohydrate overload developed Obel Grade 3 lameness within 56 h. Increases in plasma endotoxin from control levels of less than 0.1 ng/litre to values ranging from 2.4 to 81.53 ng/litre were measured in 11 (85 per cent) of 13 horses during the onset of Obel Grade 3 lameness. Obel Grade 3 lameness was associated with rises in plasma Gram‐negative endotoxin levels in 11 (92 per cent) of 12 horses. Two peak increases separated by 16 h were verified in five (45 per cent) of 11 horses that exhibited both endotoxaemia and Obel Grade 3 lameness. The first peak occurred, on average, at 32 h and (he second peak at 48 h post overload when only one peak was measured, this occurred in four horses at the average time of 24 h whereas in another three horses only a 48 h or 56 h peak was detected after carbohydrate overload. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Journal Wiley

Plasma endotoxin levels in horses subjected to carbohydrate induced laminitis

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Publisher
Wiley
Copyright
© 1987 EVJ Ltd
ISSN
0425-1644
eISSN
2042-3306
DOI
10.1111/j.2042-3306.1987.tb02571.x
Publisher site
See Article on Publisher Site

Abstract

Summary Thirteen (65 per cent) of 20 horses subjected to carbohydrate overload developed Obel Grade 3 lameness within 56 h. Increases in plasma endotoxin from control levels of less than 0.1 ng/litre to values ranging from 2.4 to 81.53 ng/litre were measured in 11 (85 per cent) of 13 horses during the onset of Obel Grade 3 lameness. Obel Grade 3 lameness was associated with rises in plasma Gram‐negative endotoxin levels in 11 (92 per cent) of 12 horses. Two peak increases separated by 16 h were verified in five (45 per cent) of 11 horses that exhibited both endotoxaemia and Obel Grade 3 lameness. The first peak occurred, on average, at 32 h and (he second peak at 48 h post overload when only one peak was measured, this occurred in four horses at the average time of 24 h whereas in another three horses only a 48 h or 56 h peak was detected after carbohydrate overload.

Journal

Equine Veterinary JournalWiley

Published: Jan 1, 1987

References

  • Changes in the caecal flora associated with the onset of laminitis
    Garner, Garner; Sprouse, Sprouse; Hutcheson, Hutcheson; Salem, Salem; Moore, Moore; Johnson, Johnson; Clarke, Clarke; Amend, Amend; Tritschler, Tritschler; Coffman, Coffman
  • Haematological changes during development of acute laminitis hypertension
    Moore, Moore; Garner, Garner; Coffman, Coffman
  • The effect of cortisone on the Shwartzman reaction
    Thomas, Thomas; Good, Good

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