AbbreviationsCIconfidence intervalCVcoefficient of variationIUGRintrauterine growth restrictionORodds ratioPEpreeclampsiaKey MessagePlacentation after placenta‐related complications is largely understudied, but available evidence suggests that placental histology is altered after placenta‐related complications in previous pregnancies. Future research should assess in vivo placentation in women with a history of placenta‐related complications to study these associations.IntroductionEvery year, over 7 million women worldwide develop pregnancy complications that are, at least in part, due to abnormal placental development and functioning and can therefore be referred to as placenta‐related complications. These pregnancy complications, such as recurrent miscarriage, pregnancy‐induced hypertension, preeclampsia (PE), intrauterine growth restriction (IUGR) and preterm delivery, are associated not only with abnormal placental development and function, but also with cardiovascular disease in mothers and their offspring in later life .In the first weeks of pregnancy, placental development is crucial, with the physiological vascular transformation of the spiral arteries into low‐resistance vessels as a result of upregulation of maternal inflammatory responses and circulatory changes . This process demands intense effort of a woman's vascular capacity and as such pregnancy is considered a stress test for cardiovascular health . Women failing this stress test are not only at risk to develop placenta‐related complications in their current pregnancy, but their risk for recurrence
Acta Obstetricia Et Gynecologica Scandinavica – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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