Abbreviations2‐DEtwo‐dimensional electrophoresisCANacetonitrileCHAPS3‐[(3‐cholamidopropyl)‐dimethylammonio]‐1‐propanesulfonateDMEMDulbecco's Modified Eagle's MediaEGFepidermal growth factorEGFRepidermal growth factor receptorFUBP1far upstream element‐binding protein 1GCgastric cancerIEFisoelectric focusingIPGimmobilized pH gradientPKG IItype II cGMP‐dependent protein kinaseRTKsreceptor tyrosine kinasesIntroductionEpidermal growth factor receptor (EGFR) is a trans‐membrane glycoprotein which contains extracellular, trans‐membrane, and tyrosine kinase domains (Lemmon and Schlessinger, ). The over‐expression of EGF and EGFR shows correlation with metastasis, resistance to chemotherapy, and poor prognosis of numerous cancers (Tahara et al., ; Mitani et al., ; Yu et al., ). For example, many research data showed that EGF and EGFR were up‐regulated in gastric cancer (GC), and were involved in the invasion and metastasis of the tumor (Ito et al., ; Yasui et al., , ; Yoshida et al., ). After binding with natural ligands, such as EGF and TGF‐α, EGFRs undergo dimerization, auto‐phosphorylation and activation (Warren and Landgraf, ). The activated EGFR recruits adapter proteins, including GRB2, PLC and Cbl, to trigger downstream signaling (Ullrich and Schlessinger, ) and induce the changes of biological activities of the cells, such as proliferation, migration, and apoptosis (Citri and Yarden, ; Ferguson, ; Kim et al., ). Type II cGMP dependent protein kinase (PKG II) is a serine/threonine kinase and displays an important role in
Cell Biology International – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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