PHOSPHOLIPID METABOLISM IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: ACTIVITY OF BRAIN PHOSPHOLIPASE A 1 , TOWARDS SPECIFICALLY LABELLED GLYCEROPHOSPHOLIPIDS

PHOSPHOLIPID METABOLISM IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: ACTIVITY OF BRAIN... —The activity of phospholipase A1 (phosphatide acylhydrolase, EC 3.1.1.4) was measured against phosphatidylcholine, ‐ethanolamine and ‐serine, specifically labelled with different fatty acids at either the 1 or 2 position, during experimental allergic encephalomyelitis in rats. In the acute stage of the disease there was a significant increase in enzyme activity in comparison to that from the control animals. The enhanced phospholipase A1 activity was of the‐same order of magnitude for all 1,2‐diacyl‐glycerophospholipids investigated. The phospholipase A1‐catalysed release of labelled fatty acids from molecular species of phosphatidylcholine decreased slightly with increasing degree of unsaturation of the fatty acids at the 1‐position. The Km‐values of the highly purified enzyme were not altered by the demyelinating disorder. The phospholipase A1 activity returned to the control level in the recovery stage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

PHOSPHOLIPID METABOLISM IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: ACTIVITY OF BRAIN PHOSPHOLIPASE A 1 , TOWARDS SPECIFICALLY LABELLED GLYCEROPHOSPHOLIPIDS

Journal of Neurochemistry, Volume 23 (4) – Oct 1, 1974

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Publisher
Wiley
Copyright
Copyright © 1974 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1974.tb04398.x
Publisher site
See Article on Publisher Site

Abstract

—The activity of phospholipase A1 (phosphatide acylhydrolase, EC 3.1.1.4) was measured against phosphatidylcholine, ‐ethanolamine and ‐serine, specifically labelled with different fatty acids at either the 1 or 2 position, during experimental allergic encephalomyelitis in rats. In the acute stage of the disease there was a significant increase in enzyme activity in comparison to that from the control animals. The enhanced phospholipase A1 activity was of the‐same order of magnitude for all 1,2‐diacyl‐glycerophospholipids investigated. The phospholipase A1‐catalysed release of labelled fatty acids from molecular species of phosphatidylcholine decreased slightly with increasing degree of unsaturation of the fatty acids at the 1‐position. The Km‐values of the highly purified enzyme were not altered by the demyelinating disorder. The phospholipase A1 activity returned to the control level in the recovery stage.

Journal

Journal of NeurochemistryWiley

Published: Oct 1, 1974

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