—The activity of phospholipase A1 (phosphatide acylhydrolase, EC 188.8.131.52) was measured against phosphatidylcholine, ‐ethanolamine and ‐serine, specifically labelled with different fatty acids at either the 1 or 2 position, during experimental allergic encephalomyelitis in rats. In the acute stage of the disease there was a significant increase in enzyme activity in comparison to that from the control animals. The enhanced phospholipase A1 activity was of the‐same order of magnitude for all 1,2‐diacyl‐glycerophospholipids investigated. The phospholipase A1‐catalysed release of labelled fatty acids from molecular species of phosphatidylcholine decreased slightly with increasing degree of unsaturation of the fatty acids at the 1‐position. The Km‐values of the highly purified enzyme were not altered by the demyelinating disorder. The phospholipase A1 activity returned to the control level in the recovery stage.
Journal of Neurochemistry – Wiley
Published: Oct 1, 1974
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