U L F PIPKORN ENT-Department, Univer.sity Hospital, Lund, Sweden Key words: allergen; bronchial challenge; nasal challenge; pharmacology. Background The allergen skin test has become one of the fundamental ingredients of the clinical allergy work-up. A question frequently encountered is which of our common pharmacological agents used for treating allergic disease has an influence on the results of the skin tests. The questions regarding pharmacological influence are often extended to the influence on other target organs of local provocation, such as the nose, conjunctiva and bronchus. Which agents should be avoided before tests? How long should the agents be avoided before testing in order to be sure that a valid result is obtained? This review will deal with the major groups of therapeutic agents currently used for allergic diseases and asthma. The review is not intended to be complete in all details, but rather to provide some basis for simple guide-lines in the practical clinical management. One should be aware that the effects of these agents are mostly inhibitory; this means that we might obtain false negative results from an allergen test under the influence of a pharmacological agent. However, this also means that a positive result should be
Allergy – Wiley
Published: Feb 1, 1988
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