Pharmacological influence of antiallergic medication on in vivo allergen testing

Pharmacological influence of antiallergic medication on in vivo allergen testing U L F PIPKORN ENT-Department, Univer.sity Hospital, Lund, Sweden Key words: allergen; bronchial challenge; nasal challenge; pharmacology. Background The allergen skin test has become one of the fundamental ingredients of the clinical allergy work-up. A question frequently encountered is which of our common pharmacological agents used for treating allergic disease has an influence on the results of the skin tests. The questions regarding pharmacological influence are often extended to the influence on other target organs of local provocation, such as the nose, conjunctiva and bronchus. Which agents should be avoided before tests? How long should the agents be avoided before testing in order to be sure that a valid result is obtained? This review will deal with the major groups of therapeutic agents currently used for allergic diseases and asthma. The review is not intended to be complete in all details, but rather to provide some basis for simple guide-lines in the practical clinical management. One should be aware that the effects of these agents are mostly inhibitory; this means that we might obtain false negative results from an allergen test under the influence of a pharmacological agent. However, this also means that a positive result should be http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Allergy Wiley

Pharmacological influence of antiallergic medication on in vivo allergen testing

Allergy, Volume 43 (2) – Feb 1, 1988

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Publisher
Wiley
Copyright
Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0105-4538
eISSN
1398-9995
DOI
10.1111/j.1398-9995.1988.tb00398.x
Publisher site
See Article on Publisher Site

Abstract

U L F PIPKORN ENT-Department, Univer.sity Hospital, Lund, Sweden Key words: allergen; bronchial challenge; nasal challenge; pharmacology. Background The allergen skin test has become one of the fundamental ingredients of the clinical allergy work-up. A question frequently encountered is which of our common pharmacological agents used for treating allergic disease has an influence on the results of the skin tests. The questions regarding pharmacological influence are often extended to the influence on other target organs of local provocation, such as the nose, conjunctiva and bronchus. Which agents should be avoided before tests? How long should the agents be avoided before testing in order to be sure that a valid result is obtained? This review will deal with the major groups of therapeutic agents currently used for allergic diseases and asthma. The review is not intended to be complete in all details, but rather to provide some basis for simple guide-lines in the practical clinical management. One should be aware that the effects of these agents are mostly inhibitory; this means that we might obtain false negative results from an allergen test under the influence of a pharmacological agent. However, this also means that a positive result should be

Journal

AllergyWiley

Published: Feb 1, 1988

References

  • Allergen induced nasal hyperreactivity appears unrelated to the size of the nasal and dermal immediate allergic reaction
    Andersson, Andersson; Kogerer, Kogerer; Andersson, Andersson; Pipkorn, Pipkorn
  • Topical sodium cromoglycate in atopic dermatitis. A disappointing but informative trial
    Kjellman, Kjellman; Gustafsson, Gustafsson
  • Effects of some drugs applied topically to the nasal mucosa before nasal provocation tests with allergen
    Pelikan, Pelikan; Vries, Vries
  • Effect of beclomethasone dipropionate aerosol on allergen induced nasal stenosis
    Vilsviik, Vilsviik; Jensen, Jensen; Walstad, Walstad

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