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Richard Miller, Peter Kelly, John Neumeyer (1976)
Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain.European journal of pharmacology, 35 1
S. Lindt, H. Lauener, E. Eichenberger (1971)
The toxicology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine (clozapine).Il Farmaco; edizione pratica, 26 10
U. Ungerstedt (1971)
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.Acta physiologica Scandinavica. Supplementum, 367
G. Stille, H. Lauener, E. Eichenberger (1971)
The pharmacology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine (clozapine).Il Farmaco; edizione pratica, 26 10
(1980)
Behavioural responses to stereotactically
Donald Bren, E. Tchetgen (2022)
Nonparametric Statistics for the Behavioral SciencesThe SAGE Encyclopedia of Research Design
IRWIN IRWIN (1968)
Comprehensive observational assessment: 1 (a) A systematic qualitative procedure for assessing the behavioural and physiologic state of the mousePsychopharmat., 13
P. Setler, H. Sarau, C. Zirkle, H. Saunders (1978)
The central effects of a novel dopamine agonist.European journal of pharmacology, 50 4
Roth Rh (1979)
Dopamine autoreceptors: pharmacology, function and comparison with post-synaptic dopamine receptors.Communications in psychopharmacology, 3
B. Costall, R. Naylor (1976)
Apomorphine as an antagonist of the dopamine response from the nucleus accumbensJournal of Pharmacy and Pharmacology, 28
ROTH ROTH (1979)
Dopamine autoreceptors: pharmacology, function and comparisons with post‐synaptic dopamine receptorsPsychopharm. Commun., 3
B. Costall, R. Naylor, J. Neumeyer (1975)
Differences in the nature of the stereotyped behaviour induced by aporphine derivatives in the rat and in their actions in extrapyramidal and mesolimbic brain areas.European journal of pharmacology, 31 1
N. Krieger (1980)
Localization of dopamine-sensitive adenylate cyclase within the rat olfactory tubercleBrain Research, 183
(1968)
Comprehensive observational assessment: 1
(1959)
In The Rat Forebrain in Stereotaxic Co-ordinates
MAKANJUOLA MAKANJUOLA, DOW DOW, ASHCROFT ASHCROFT (1980)
Behavioural responses to stereotactically controlled injections of monoamine neurotransmitters into the accumbens and caudate putamen nucleiPsychopharmacology, 71
COSTALL COSTALL, NAYLOR NAYLOR (1974)
Specific asymmetric behaviour induced by the direct chemical stimulation of neostriatal dopaminergic mechanismsNaunyn-Schmiedebergs Arch. Pharmac., 285
(1981)
Pre-clinical studies of the pharmacology of aporphines
P. Seeman (1980)
Brain dopamine receptors.Pharmacological reviews, 32 3
J. Cannon, T. Lee, H. Goldman (1977)
Cerebral dopamine agonist properties of some 2-aminotetralin derivatives after peripheral and intracerebral administration.Journal of medicinal chemistry, 20 9
U. Ungerstedt, G. Arbuthnott (1970)
Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.Brain research, 24 3
U. Ungerstedt (1971)
Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.Acta physiologica Scandinavica. Supplementum, 367
1 The relative potencies of dopamine receptor agonists in causing stereotypy in rats when injected into the olfactory tubercles, and contralateral rotation when injected unilaterally into the caudate nucleus of rats with lesions of the nigro‐striatal dopamine pathway, were determined. The actions of some agonists in eliciting these responses following peripheral injection, and the relative potencies of dopamine receptor antagonists in inhibiting them were also determined. 2 Dopamine, apomorphine and 2‐amino‐5, 6 and 2‐amino‐6, 7‐dihydroxy‐1,2,3,4‐tetrahydronaphthalene (A‐5, 6 DTN, A‐6, 7 DTN) and N,N dipropyl A‐5, 6DTN induced both responses. In contrast, 2,3,4,5‐tetrahydro‐7,8‐dihydroxy‐1‐phenyl‐1H‐3‐benzazepine HCl (SK & F 38393) whether injected intracerebrally or peripherally, induced contralateral rotation but not stereotypy. 3 Contralateral rotation and stereotypy induced by apomorphine or N,N dipropyl A‐5, 6 DTN were inhibited by haloperidol, pimozide and fluphenazine but these drugs failed to inhibit rotation induced by SK & F 38393. Clozapine inhibited rotation induced by SK & F 38393, apomorphine or N,N dipropyl A‐5, 6 DTN but failed to inhibit stereotypy. Loxapine was more potent in inhibiting stereotypy than rotation, whereas clothiapine inhibited rotation and stereotypy at similar doses irrespective of the agonist used to elicit the response. 4 Contralateral rotation induced by SK & F 38393 was not inhibited by yohimbine, prazosin, atropine, methysergide, mepyramine or propranolol. 5 The results provide evidence that contralateral rotation induced by dopamine receptor agonists is mediated by two different classes of dopamine receptors and that these receptors differ from those mediating the stereotypy response. 6 The receptors mediating these responses appear classifiable in terms of their sensitivity to the agonist actions of SK & F 38393 or apomorphine respectively. SK & F 38393‐sensitive receptors are susceptible to blockade by clozapine but are not blocked by haloperidol, pimozide or fluphenazine. Apomorphine‐sensitive receptors are susceptible to blockade by haloperidol, pimozide and fluphenazine but appear divisible into two sub‐classes depending on whether or not they are blocked by clozapine and on their sensitivity to blockade by loxapine.
British Journal of Pharmacology – Wiley
Published: Sep 1, 1982
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