Persicarin from water dropwort ( Oenanthe javanica ) protects primary cultured rat cortical cells from glutamate‐induced neurotoxicity

Persicarin from water dropwort ( Oenanthe javanica ) protects primary cultured rat cortical cells... The n‐BuOH fraction of O. javanica significantly protected the primary cultures of rat cortical cells exposed to glutamate. Four flavonoids yielded from this fraction through bioactivity‐guidance. The isolated compounds, identified as isorhamnetin (1), afzelin (2), hyperoside (3) and persicarin (4), were evaluated in vitro for their neuroprotective activity. Persicarin (4), the main constituent of O. javanica, showed significant neuroprotective activities in glutamate‐injured rat cortical cells. Persicarin diminished calcium influx and inhibited the subsequent overproduction of nitric oxide and intracellular peroxide. In addition, persicarin significantly restored the reduced activities of glutathione (GSH) reductase and glutathione peroxidase, and the contents of GSH induced by glutamate. These results support a conclusion that persicarin greatly contributes to the neuroprotective activities of O. javanica. Copyright © 2009 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Phytotherapy Research Wiley

Persicarin from water dropwort ( Oenanthe javanica ) protects primary cultured rat cortical cells from glutamate‐induced neurotoxicity

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Publisher
Wiley
Copyright
Copyright © 2009 John Wiley & Sons, Ltd.
ISSN
0951-418X
eISSN
1099-1573
D.O.I.
10.1002/ptr.3065
Publisher site
See Article on Publisher Site

Abstract

The n‐BuOH fraction of O. javanica significantly protected the primary cultures of rat cortical cells exposed to glutamate. Four flavonoids yielded from this fraction through bioactivity‐guidance. The isolated compounds, identified as isorhamnetin (1), afzelin (2), hyperoside (3) and persicarin (4), were evaluated in vitro for their neuroprotective activity. Persicarin (4), the main constituent of O. javanica, showed significant neuroprotective activities in glutamate‐injured rat cortical cells. Persicarin diminished calcium influx and inhibited the subsequent overproduction of nitric oxide and intracellular peroxide. In addition, persicarin significantly restored the reduced activities of glutathione (GSH) reductase and glutathione peroxidase, and the contents of GSH induced by glutamate. These results support a conclusion that persicarin greatly contributes to the neuroprotective activities of O. javanica. Copyright © 2009 John Wiley & Sons, Ltd.

Journal

Phytotherapy ResearchWiley

Published: Jun 1, 2010

References

  • Glutamate neurotoxicity is associated with nitric oxide‐mediated mitochondrial dysfunction and glutathione depletion
    Almeida, Almeida; Heales, Heales; Bolanos, Bolanos; Medina, Medina
  • Identification and quantification of major polyphenols in apple pomace
    Lu, Lu; Foo, Foo
  • Meso‐dihydroguaiaretic acid and licarin A of Machilus thunbergii protect against glutamate‐induced toxicity in primary cultures of a rat cortical cells
    Ma, Ma; Kim, Kim; Kim, Kim; Kim, Kim
  • Meso‐Dihydroguaiaretic acid attenuates the neurotoxic effect of staurosporine in primary rat cortical cultures
    Ma, Ma; Lee, Lee; Kim, Kim
  • Effects of methanol extract of Oenanthe javanica on the hepatic alcohol‐metabolizing enzyme system and its bioactive component
    Park, Park; Choi, Choi

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