INTRODUCTIONPeriodontitis is an infectious disease of the periodontal tissues (Page & Kornman, ). It is one of the main causes of periodontal pockets, progressive attachment loss and frontal absorption, which finally leads to loosening and loss of the tooth (Haytac, Ozcelik, & Mariotti, ). The ideal treatment of periodontitis is the formation of new periodontal attachment (Han, Menicanin, Gronthos, & Bartold, ), but the traditional treatment methods including periodontal basic treatment, periodontal surgery cannot achieve the ideal goal (Menicanin, Hynes, Han, Gronthos, & Bartold, ). Over the years, the rapid development of tissue engineering theory and technology provides a new idea for periodontal tissue regeneration (Iwata, Yamato, Ishikawa, Ando, & Okano, ).Cells, scaffolds and growth factors are the three main elements needed for creating a tissue‐engineered construct (Janicki & Schmidmaier, ). Human dental follicle cells (HDFCs), which are easily accessible and have stem cell properties, have received wide attention in the field of periodontal tissue engineering (Akizuki et al., ). However, separated cells have difficulty in colonization because they lack the extracellular matrix and bioactive molecule (Charwat et al., ; Kawaguchi et al., ), besides, during inoculation, some of the cells will lose which will cause the low efficiency of the surgery
Oral Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ;
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