ABBREVIATIONSBRblood rotationTA‐GVHDtransfusion‐associated graft‐versus‐host diseaseThe Ogasawara Islands are located approximately 1000 km south of Tokyo in the Pacific Ocean and consist of about 30 islands. Two of these islands are inhabited, with a population of approximately 2600 people, and two clinics are present on each island. The Ogasawara Islands do not have an airport and can only be accessed from Tokyo by a 25‐hour voyage aboard a ship, which did not have refrigeration for the storage of blood products until April 2014. These ships are scheduled to sail once a week. If patients on the island experienced acute hemorrhage and required an emergency blood transfusion, then people living on the island would donate fresh blood. Therefore, the Ogasawara blood rotation (BR) system was established to rescue patients with acute hemorrhage or severe anemia and to avoid the use of fresh blood transfusions, which potentially can induce transfusion‐associated graft‐versus‐host disease (TA‐GVHD). TA‐GVHD is one of the most serious hazards of transfusions in Japan, which has the highest frequency of TA‐GVHD worldwide. Mortality from TA‐GVHD has been estimated to be between 90% and 100%. Since the introduction of irradiation of all cellular components by Japanese Red Cross Blood Centers in 2000, there
Transfusion – Wiley
Published: Jan 1, 2018
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