Pathways to the Secretion of Adrenocorticotropin: A View from the Portal *

Pathways to the Secretion of Adrenocorticotropin: A View from the Portal * Paul M. Plotsky The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California, USA Key words corticotropin-releasing factor, arginine vasopressin, adrenocorticotropin, corticosterone, catecholamines Foremost among physiological concepts is that of constancy of the milieu interior first introduced by Claude Bernard ( I ) and extended by Walter Cannon (2), who coined the term homeostasis. Cannon was among the first to recognize the pivotal role played by the CNS in coordinating the many processes which ensure a relative constancy of the internal environment. Activation of the hypothalamic-pituitary-adrenal (HPA) axis is one of the many systems designed to maintain homeostatic balance in response to a diversity of challenges. Indeed, in the absence of glucocorticoids, even moderate stressors can threaten survival. The role of the adrenal cortex as a primary effector mediating homeostasis was strongly advanced by Seyle (3) and reinforced by an impressive body of observations (4-8). The detailed anatomical observations of Popa and Fielding (9), Houssay et al. (lo), and Wislocki and King (1 1) established the unique nature of the hypophysial-portal vasculature and, eventually provided a morphological foundation to our current understanding of neuroendocrine communication. The combination of this anatomical foundation with the work of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroendocrinology Wiley

Pathways to the Secretion of Adrenocorticotropin: A View from the Portal *

Journal of Neuroendocrinology, Volume 3 (1) – Feb 1, 1991

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Publisher
Wiley
Copyright
Copyright © 1991 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0953-8194
eISSN
1365-2826
DOI
10.1111/j.1365-2826.1991.tb00231.x
pmid
19215439
Publisher site
See Article on Publisher Site

Abstract

Paul M. Plotsky The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California, USA Key words corticotropin-releasing factor, arginine vasopressin, adrenocorticotropin, corticosterone, catecholamines Foremost among physiological concepts is that of constancy of the milieu interior first introduced by Claude Bernard ( I ) and extended by Walter Cannon (2), who coined the term homeostasis. Cannon was among the first to recognize the pivotal role played by the CNS in coordinating the many processes which ensure a relative constancy of the internal environment. Activation of the hypothalamic-pituitary-adrenal (HPA) axis is one of the many systems designed to maintain homeostatic balance in response to a diversity of challenges. Indeed, in the absence of glucocorticoids, even moderate stressors can threaten survival. The role of the adrenal cortex as a primary effector mediating homeostasis was strongly advanced by Seyle (3) and reinforced by an impressive body of observations (4-8). The detailed anatomical observations of Popa and Fielding (9), Houssay et al. (lo), and Wislocki and King (1 1) established the unique nature of the hypophysial-portal vasculature and, eventually provided a morphological foundation to our current understanding of neuroendocrine communication. The combination of this anatomical foundation with the work of

Journal

Journal of NeuroendocrinologyWiley

Published: Feb 1, 1991

References

  • Neural control of the pituitary gland
    Harris, Harris
  • Mediation by corticotropin releasing factor (CRF) of adenohypophysial hormone secretion
    Rivier, Rivier; Plotsky, Plotsky
  • Lack of correlation between immunoreactive corticotropin‐releasing factor concentration profiles in hypophysial‐portal and peripheral plasma
    Plotsky, Plotsky; Otto, Otto; Toyama, Toyama; Sutton, Sutton
  • Pituitary blood flow
    Page, Page
  • Neural pathways mediating the effects of afferent stimuli on paraventricular nucleus multiunit activity in freely‐moving rats
    Mor, Mor; Saphier, Saphier; Feldman, Feldman
  • Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
    Swanson, Swanson; Sawchenko, Sawchenko
  • Hypothalamic receptors influencing the secretion of corticotrophin‐releasing hormone in the rat
    Buckingham, Buckingham; Hodges, Hodges
  • Inhibition in corticotrophin and corticosterone secretion following photic stimulation in rats with 6‐hydroxydopamine injection into the medial forebrain bundle
    Feldman, Feldman; Melamed, Melamed; Conforti, Conforti; Weidenfeld, Weidenfeld
  • Neuropeptide Y in the hypothalamus: effect on corticosterone and single unit activity
    Albers, Albers; Ottenweller, Ottenweller; Liou, Liou; Lumpkin, Lumpkin; Anderson, Anderson
  • Demonstration of glucocorticoid receptor‐like immunoreactivity in glucocorticoid‐sensitive vasopressin and corticotropin‐releasing factor neurons in the hypothalamic paraventricular nucleus
    Uht, Uht; McKelvy, McKelvy; Harrison, Harrison; Bohn, Bohn
  • Corticosterone: narrow range required for normal body and thymus weight and ACTH
    Akana, Akana; Cascio, Cascio; Shinsako, Shinsako; Dallman, Dallman
  • Potentiated response to paired hemorrhage: role of angiotensin and vasopressin
    Lilly, Lilly; DeMaria, DeMaria; Bruhn, Bruhn; Gann, Gann
  • Differential regulation of corticotropin‐releasing hormone mRNA in rat brain
    Frim, Frim; Robinson, Robinson; Pasieka, Pasieka; Mazjoub, Mazjoub

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