Pathology of retroperitoneal sarcomas: A brief review

Pathology of retroperitoneal sarcomas: A brief review INTRODUCTIONSarcomas represent the rarest form of solid tumor malignancies, accounting for <1% of tumors in the adult population with over 50 recognized histologic types, and numerous subtypes. Some of the histologic types occur with a high frequency in the retroperitoneum where their varied histologic patterns can overlap, especially in the context of limited sampling, potentially leading to a diagnostic pitfall. The diagnosis of sarcoma can, at times, be notoriously challenging for pathologists, particularly those without subspecialty expertise. Definitive classification of a tumor often requires integration of clinical history and diagnostic imaging results, in addition to judicious application of ancillary techniques such as immunohistochemistry, cytogenetics and molecular pathology. The latter is particularly important in view of the emergence of personalized medicine based of molecularly targeted therapy. In this review, we highlight pertinent pathologic and molecular aspects of sarcomas common in the retroperitoneum, relevant to the surgical oncologist.WELL‐DIFFERENTIATED LIPOSARCOMADefinitionWell‐differentiated liposarcoma (WDLS) is a locally aggressive malignant mesenchymal neoplasm composed of mature adipose tissue with nuclear atypia in either or both stromal cells and adipocytes. Tumors are characterized by sheets of adipocytes with variability in size and shape, with hyperchromatic nuclei and/or broad cellular septae containing cells with enlarged and hyperchromatic nuclei; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Surgical Oncology Wiley

Pathology of retroperitoneal sarcomas: A brief review

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-4790
eISSN
1096-9098
D.O.I.
10.1002/jso.24928
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONSarcomas represent the rarest form of solid tumor malignancies, accounting for <1% of tumors in the adult population with over 50 recognized histologic types, and numerous subtypes. Some of the histologic types occur with a high frequency in the retroperitoneum where their varied histologic patterns can overlap, especially in the context of limited sampling, potentially leading to a diagnostic pitfall. The diagnosis of sarcoma can, at times, be notoriously challenging for pathologists, particularly those without subspecialty expertise. Definitive classification of a tumor often requires integration of clinical history and diagnostic imaging results, in addition to judicious application of ancillary techniques such as immunohistochemistry, cytogenetics and molecular pathology. The latter is particularly important in view of the emergence of personalized medicine based of molecularly targeted therapy. In this review, we highlight pertinent pathologic and molecular aspects of sarcomas common in the retroperitoneum, relevant to the surgical oncologist.WELL‐DIFFERENTIATED LIPOSARCOMADefinitionWell‐differentiated liposarcoma (WDLS) is a locally aggressive malignant mesenchymal neoplasm composed of mature adipose tissue with nuclear atypia in either or both stromal cells and adipocytes. Tumors are characterized by sheets of adipocytes with variability in size and shape, with hyperchromatic nuclei and/or broad cellular septae containing cells with enlarged and hyperchromatic nuclei;

Journal

Journal of Surgical OncologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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