Pathological lesions and global DNA methylation in rat prostate under streptozotocin‐induced diabetes and melatonin supplementation

Pathological lesions and global DNA methylation in rat prostate under streptozotocin‐induced... Abbreviations5MeC5‐methylcytidineAGEAdvanced glycation end productsRAGEAdvanced glycation end products receptorAMPKAMP‐activated protein kinaseBcl‐2Anti‐apoptotic proteinC1Control animals of short‐term experimentC2Control animals of long‐term experimentM1Control animals treated with MLT of short‐term experimentM2Control animals treated with MLT of short‐term experimentDMDiabetes mellitusDABDiaminobenzidineGLUT2Glucose transporter type 2GSTPIGlutathione S‐transferase piPINIntraepithelial neoplasiaLHLuteinizing hormoneMLTMelatoninMTR1Melatonin receptor type 1D1One‐week‐diabetic ratsMD1One‐week‐diabetic rats treated with MLTPCNAProliferating cell nuclear antigenPIAProliferative inflammatory atrophyPINProstate intraepithelial neoplasiaPKAProtein kinases APKBProtein kinases BPKCProtein kinases CROSReactive oxygen speciessmcSmooth muscle cellsSTZStreptozotocinD2Two‐month‐diabetic ratsMD2Two‐month‐diabetic rats treated with MLT.IntroductionThe association between diabetes mellitus (DM) and prostate cancer is controversial. Some clinical studies have associated DM, especially type‐1, with a lower risk of prostate cancer, attributed to the protective effects of insulin lack and lower testosterone levels (Moreira et al., ; Fall et al., ; Xu et al., ; Yu et al., ). This is due because insulin regulates the production of testosterone by affecting the hypothalamic‐hypophyseal‐testes axis (Kirchick et al., ) and producing local effects through insulin receptors (Bhasin et al., ; Cáp, ). Insulin‐like growth factor 1 (IGF‐1) was identified as a major regulator of epithelial cell survival in the rat ventral prostate (Ohlson et al., ). On the other hand, poor glycemic control has been associated with higher risk of prostate cancer (Ishiguro et al., http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Biology International Wiley

Pathological lesions and global DNA methylation in rat prostate under streptozotocin‐induced diabetes and melatonin supplementation

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Publisher
Wiley
Copyright
© 2018 International Federation for Cell Biology
ISSN
1065-6995
eISSN
1095-8355
D.O.I.
10.1002/cbin.10920
Publisher site
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Abstract

Abbreviations5MeC5‐methylcytidineAGEAdvanced glycation end productsRAGEAdvanced glycation end products receptorAMPKAMP‐activated protein kinaseBcl‐2Anti‐apoptotic proteinC1Control animals of short‐term experimentC2Control animals of long‐term experimentM1Control animals treated with MLT of short‐term experimentM2Control animals treated with MLT of short‐term experimentDMDiabetes mellitusDABDiaminobenzidineGLUT2Glucose transporter type 2GSTPIGlutathione S‐transferase piPINIntraepithelial neoplasiaLHLuteinizing hormoneMLTMelatoninMTR1Melatonin receptor type 1D1One‐week‐diabetic ratsMD1One‐week‐diabetic rats treated with MLTPCNAProliferating cell nuclear antigenPIAProliferative inflammatory atrophyPINProstate intraepithelial neoplasiaPKAProtein kinases APKBProtein kinases BPKCProtein kinases CROSReactive oxygen speciessmcSmooth muscle cellsSTZStreptozotocinD2Two‐month‐diabetic ratsMD2Two‐month‐diabetic rats treated with MLT.IntroductionThe association between diabetes mellitus (DM) and prostate cancer is controversial. Some clinical studies have associated DM, especially type‐1, with a lower risk of prostate cancer, attributed to the protective effects of insulin lack and lower testosterone levels (Moreira et al., ; Fall et al., ; Xu et al., ; Yu et al., ). This is due because insulin regulates the production of testosterone by affecting the hypothalamic‐hypophyseal‐testes axis (Kirchick et al., ) and producing local effects through insulin receptors (Bhasin et al., ; Cáp, ). Insulin‐like growth factor 1 (IGF‐1) was identified as a major regulator of epithelial cell survival in the rat ventral prostate (Ohlson et al., ). On the other hand, poor glycemic control has been associated with higher risk of prostate cancer (Ishiguro et al.,

Journal

Cell Biology International – Wiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

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