Pathological lesions and global DNA methylation in rat prostate under streptozotocin‐induced diabetes and melatonin supplementation

Pathological lesions and global DNA methylation in rat prostate under streptozotocin‐induced... Abbreviations5MeC5‐methylcytidineAGEAdvanced glycation end productsRAGEAdvanced glycation end products receptorAMPKAMP‐activated protein kinaseBcl‐2Anti‐apoptotic proteinC1Control animals of short‐term experimentC2Control animals of long‐term experimentM1Control animals treated with MLT of short‐term experimentM2Control animals treated with MLT of short‐term experimentDMDiabetes mellitusDABDiaminobenzidineGLUT2Glucose transporter type 2GSTPIGlutathione S‐transferase piPINIntraepithelial neoplasiaLHLuteinizing hormoneMLTMelatoninMTR1Melatonin receptor type 1D1One‐week‐diabetic ratsMD1One‐week‐diabetic rats treated with MLTPCNAProliferating cell nuclear antigenPIAProliferative inflammatory atrophyPINProstate intraepithelial neoplasiaPKAProtein kinases APKBProtein kinases BPKCProtein kinases CROSReactive oxygen speciessmcSmooth muscle cellsSTZStreptozotocinD2Two‐month‐diabetic ratsMD2Two‐month‐diabetic rats treated with MLT.IntroductionThe association between diabetes mellitus (DM) and prostate cancer is controversial. Some clinical studies have associated DM, especially type‐1, with a lower risk of prostate cancer, attributed to the protective effects of insulin lack and lower testosterone levels (Moreira et al., ; Fall et al., ; Xu et al., ; Yu et al., ). This is due because insulin regulates the production of testosterone by affecting the hypothalamic‐hypophyseal‐testes axis (Kirchick et al., ) and producing local effects through insulin receptors (Bhasin et al., ; Cáp, ). Insulin‐like growth factor 1 (IGF‐1) was identified as a major regulator of epithelial cell survival in the rat ventral prostate (Ohlson et al., ). On the other hand, poor glycemic control has been associated with higher risk of prostate cancer (Ishiguro et al., http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Biology International Wiley

Pathological lesions and global DNA methylation in rat prostate under streptozotocin‐induced diabetes and melatonin supplementation

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Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 International Federation for Cell Biology
ISSN
1065-6995
eISSN
1095-8355
D.O.I.
10.1002/cbin.10920
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Abstract

Abbreviations5MeC5‐methylcytidineAGEAdvanced glycation end productsRAGEAdvanced glycation end products receptorAMPKAMP‐activated protein kinaseBcl‐2Anti‐apoptotic proteinC1Control animals of short‐term experimentC2Control animals of long‐term experimentM1Control animals treated with MLT of short‐term experimentM2Control animals treated with MLT of short‐term experimentDMDiabetes mellitusDABDiaminobenzidineGLUT2Glucose transporter type 2GSTPIGlutathione S‐transferase piPINIntraepithelial neoplasiaLHLuteinizing hormoneMLTMelatoninMTR1Melatonin receptor type 1D1One‐week‐diabetic ratsMD1One‐week‐diabetic rats treated with MLTPCNAProliferating cell nuclear antigenPIAProliferative inflammatory atrophyPINProstate intraepithelial neoplasiaPKAProtein kinases APKBProtein kinases BPKCProtein kinases CROSReactive oxygen speciessmcSmooth muscle cellsSTZStreptozotocinD2Two‐month‐diabetic ratsMD2Two‐month‐diabetic rats treated with MLT.IntroductionThe association between diabetes mellitus (DM) and prostate cancer is controversial. Some clinical studies have associated DM, especially type‐1, with a lower risk of prostate cancer, attributed to the protective effects of insulin lack and lower testosterone levels (Moreira et al., ; Fall et al., ; Xu et al., ; Yu et al., ). This is due because insulin regulates the production of testosterone by affecting the hypothalamic‐hypophyseal‐testes axis (Kirchick et al., ) and producing local effects through insulin receptors (Bhasin et al., ; Cáp, ). Insulin‐like growth factor 1 (IGF‐1) was identified as a major regulator of epithelial cell survival in the rat ventral prostate (Ohlson et al., ). On the other hand, poor glycemic control has been associated with higher risk of prostate cancer (Ishiguro et al.,

Journal

Cell Biology International – Wiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

  • Proliferation and apoptotic rates and increased frequency of p63‐positive cells in the prostate acinar epithelium of alloxan‐induced diabetic rats
    Arcolino, FO; Ribeiro, DL; Gobbo, MG; Taboga, SR; Góes, RM
  • A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis
    Ashour, N; Ângulo, JC; Andrés, G; Alelú, R; González‐Corpas, A; Toledo, MV; Rodríguez‐Barbero, JM; López, JI; Sánchez‐Chapado, M; Ropero, S
  • Sexual dysfunction in men and women with endocrine disorders
    Bhasin, S; Enzlin, P; Coviello, A; Basson, R
  • Inflammation and atrophy precede prostatic neoplasia in a PhIP‐induced rat model
    Borowsky, AD; Dingley, KH; Ubick, E; Turteltaub, KW; Cardiff, RD; Devere‐White, R
  • Global hypomethylation is common in prostate cancer cells: a quantitative predictor for clinical outcome
    Brothman, AR; Swanson, G; Maxwell, TM; Cui, J; Murphy, KJ; Herrick, J; Speights, VO; Isaac, J; Rohr, LR
  • Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
    Cagnon, VH; Camargo, AM; Rosa, RM; Fabiani, R; Padovani, CR; Martinez, FE
  • Infections in diabetes
    Calvet, HM; Yoshikawa, TT
  • Androgen deficit and diabetes
    Cáp, J
  • Melatonin role in experimental arthritis
    Cardinali, DP; García, AP; Cano, P; Esquifino, AI
  • A review of the multiple actions of melatonin on the immune system
    Carrillo‐Vico, A; Guerrero, JM; Lardone, PJ; Reiter, RJ
  • Effects of experimental diabetes on the structure and ultrastructure of the coagulating gland of C57BL/6J and NOD mice
    Carvalho, HF; Camargo, M; Cagnon, VH; Padovani, CR
  • Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury
    Cuzzocrea, S; Reiter, RJ
  • Melatonin intake since weaning ameliorates steroidogenic function and sperm motility of streptozotocin‐induced diabetic rats
    da Costa, CF; Gobbo, MG; Taboga, SR; Pinto‐Fochi, ME; Góes, RM
  • Estrogen receptor beta‐mediated inhibition of male germ cell line development in mice by endogenous estrogens during perinatal life
    Delbès, G; Levacher, C; Pairault, C; Racine, C; Duquenne, C; Krust, A; Habert, R
  • Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis
    De Marzo, AM; Marchi, VL; Epstein, JI; Nelson, WG
  • Human prostate cancer precursors and pathobiology
    De Marzo, AM; Meeker, AK; Zha, S; Luo, J; Nakayama, M; Platz, EA; Isaacs, WB; Nelson, WG
  • Functional MT1 and MT2 melatonin receptors in mammals
    Dubocovich, ML; Markowska, M
  • Oxidative stress and stress‐activated signaling pathways: a unifying hypothesis of type 2 diabetes
    Evans, JL; Goldfine, ID; Maddux, BA; Grodsky, GM
  • Diabetes mellitus and prostate cancer risk; a nationwide case‐control study within PCBaSe Sweden
    Fall, K; Garmo, H; Gudbjornsdottir, S; Stattin, P;; zethelius, B
  • Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate
    Fávaro, WJ; Cagnon, VHA
  • Ultrastructural and proliferative features of the ventral lobe of the prostate in non‐obese diabetic mice (NOD) following androgen and estrogen replacement associated to insulin therapy
    Fávaro, WJ; Padovani, CR; Cagnon, VH
  • Efficacy and safety of prolonged‐release melatonin in insomnia patients with diabetes: a randomized, double‐blind, crossover study
    Garfinkel, D; Zorin, M; Wainstein, J; Matas, Z; Laudon, M; Zisapel, N
  • Oxidative stress and diabetic complications
    Giacco, F; Brownlee, M
  • Biomarkers of oxidative stress in rat male reproductive organs under experimental diabetes and interference of melatonin treatment
    Gobbo, MG; Costa, CFP; Silva, DGH; Almeira, EA; Góes, RM
  • Proliferative and apoptotic responses of the prostate under normal and hyperglycemic conditions
    Gobbo, MG;; Dizeyi, N;; Abrahamsson, PA;; Bertilsson, PA;; Masitéli, VS;; Pytlowanciv, EZ;; Taboga, SR; Góes, RM
  • Short‐term stromal alterarions in the rat ventral prostate following alloxan‐induced diabetes and influence of insulin replacement
    Gobbo, MG; Ribeiro, DL; Taboga, SR; Goes, RM
  • Oxidative stress markers and apoptosis in the prostate of diabetic rats and the influence of vitamin C treatment
    Gobbo, MG; Ribeiro, DL; Taboga, SR; de Almeida, EA; Góes, RM
  • A new proposed rodent model of chemically induced prostate carcinogenesis: Distinct time‐course prostate cancer progression in the dorsolateral and ventral lobes
    Gonçalves, BF; de Campos, SG; Zanetoni, C; Scarano, WR; Falleiros, LR; Amorim, RL; Góes, RM; Taboga, SR
  • Prostate carcinogenesis with diabetes and androgen‐deprivation‐therapy‐related diabetes: an update
    Hara, N
  • Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer
    Hevia, D; González‐Menéndez, P; Quiros‐González, I; Miar, A; Rodríguez‐García, A; Tan, DX; Reiter, RJ; Mayo, JC; Sainz, RM
  • Experimental diabetes‐induced regression of the rat prostate is associated with an increased expression of transforming growth factorbeta
    Ikeda, K; Wada, Y; Foster, HE; Wang, Z; Weiss, RM; Latifpour, J
  • Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice
    Ikemura, M; Nishikawa, M; Kusamori, K; Fukuoka, M; Yamashita, F; Hashida, M
  • Receptor for advanced glycation end products (RAGE) and its ligand, amphoterinare overexpressed and associated with prostate cancer development
    Ishiguro, H; Nakaigawa, N; Miyoshi, y; Fujinami, K; Kubota, Y; Uemura, H
  • Protective effects of melatonin on retinal inflammation and oxidative stress in experimental diabetic retinopathy
    Jiang, T; Chang, Q; Cai, J; Fan, J; Zhang, X; Xu, G
  • Autoradiographic study of the distribution and cellularuptake of (14C)‐streptozotocin in the rat
    Karunanayake, EH; Baker, JR; Christian, RA; Hearse, DJ; Mellows, G
  • An explanation for anovulation in immature alloxan‐diabetic rats treated with pregnant mare's serum gonadotropin: reduced pituitary response to gonadotropin‐releasing hormone
    Kirchick, HJ; Keyes, PL; Frye, BE
  • Melatonin: an established antioxidant worthy of use in clinical trials
    Korkmaz, A; Reiter, RJ; Topal, T; Manchester, LC; Oter, S; Dun‐Xian, T
  • Hyperglycemic memory in metabolism and cancer
    Lee, C; An, D; J, Park
  • Diabetes and mortality in patients with prostate cancer: a meta‐analysis
    Lee, J; Giovannucci, E; Jeon, JY
  • The mechanisms of alloxan‐ and streptozotocin‐induced diabetes
    Lenzen, S
  • Anti‐inflammatory actions of melatonin and its metabolites, N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK) and N1‐acetyl‐5‐methoxykynuramine (AMK), in macrophages
    Mayo, JC; Sainz, RM; Tan, DX; Hardeland, R; Leon, J; Rodriguez, C; Reiter, RJ
  • Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon and lung cancer
    Miar, A; Hevia, D; Muñoz‐Cimadevilla, H; Astudillo, A; Velasco, J; Sainz, RM; Mayo, JC
  • Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma
    Mohamed, MA; Greif, PA; Diamond, J; Sharaf, O; Maxwell, P; Montironi, R; Young, RA; Hamilton, PW
  • Oxidative stress in diabetic rats induced by streptozotocin: protective effects of melatonin
    Montilla, PL; Vargas, JF; Túnez, IF; Muñoz de Agueda, MC; Valdelvira, ME; Cabrera, ES
  • The association of diabetes mellitus and high‐grade prostate cancer in a multiethnic biopsy series
    Moreira, DM; Anderson, T; Gerber, L; Thomas, JA; Bañez, LL; McKeever, MG; Freedland, SJ
  • Castration rapidly decreases local insulin‐like growth factor‐1 levels and inhibits its effects in the ventral prostate in mice
    Ohlson, N; Bergh, A; Persson, ML; Wikström, P
  • Melatonin modulates the immune system response and inflammation in diabetic rats experimentally‐induced by alloxan
    Ozkanlar, S; Kara, A; Sengul, E; Simsek, N; Karadeniz, A; Kurt, N
  • Prostate carcinogenesis and inflammation: emerging insights
    Palapattu, GS; Sutcliffe, S; Bastian, PJ; Platz, EA; De Marzo, AM; Isaacs, WB; Nelson, WG
  • Melatonin—Naturés most versatile biological signal
    Pandi‐Perumal, SR; Srinivasan, V; Maestroni, GJM; Cardinali, DP;; Poeggeler, B
  • Poor glycemic control of diabetes mellitus is associated with higher risk of prostate cancer detection in a biopsy population
    Park, J; Cho, SY; Lee, YJ; Lee, SB; Son, H; Jeong, H
  • Oxidative stress in prostate cancer: changing research concepts towards a novel paradigm for prevention and therapeutics
    Paschos, A; Pandya, R; Duivenvoorden, WC; Pinthus, JH
  • Lobund‐Wistar rat model of prostate cancer in man
    Pollard, M
  • A genomic analysis of rat proteases and protease inhibitors
    Puente, XS; López‐Otín, C
  • Spontaneous neoplasms in control Wistar rats: a comparison of reviews
    Poteracki, J; Walsh, KM
  • Androgen regulation of host defenses and response to inflammatory stimuli in the prostate gland
    Quintar, AA;; Maldonado, CA
  • Lipoxygenase‐mediated pro‐radical effect of melatonin via stimulation of arachidonic acid metabolism
    Radogna, F; Sestili, P; Martinelli, C; Paolillo, M; Paternoster, L; Albertini, MC; Accorsi, A; Gualandi, G; Ghibelli, L
  • Melatonin: lowering the high price of free radicals
    Reiter, RJ
  • Prostatic stromal microenvironment and experimental diabetes
    Ribeiro, DL; Candido, EM; Caldeira, E; Manzato, AJ; Taboga, SR; Cagnon, VHA
  • AKT and AMPK activation after high‐fat and high‐glucose in vitro treatment of prostate epithelial cells
    Ribeiro, DL; Góes, RM; Pinto‐Fochi, ME; Taboga, SR; Abrahamsson, PA; Dizeyi, N
  • Malignant lesions in the ventral prostate of alloxan‐induced diabetic rats
    Ribeiro, DL; Marques, SF; Alberti, S; Spadella, CT; Manzato, AJ; Taboga, SR; Dizeyi, N; Abrahamsson, PA; Góes, RM
  • Diabetes induces stromal remodelling and increase in chondroitin sulfate proteoglycans of the rat ventral prostate
    Ribeiro, DL; Taboga, SR; Góes, RM
  • Desquamation is a novel phenomenon for collective prostate epithelial cell deletion after castration
    Rosa‐Ribeiro, R; Barbosa, GO; Kühne, F; Carvalho, HF
  • Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism
    Sainz, RM; Mayo, JC; Tan, D; León, J; Manchester, L; Reiter, RJ
  • Inflammation and chronic prostatic diseases: evidence for a link
    Sciarra, A; Di Silverio, F; Salciccia, S; Autran Gomez, AM; Gentilucci, A; Gentile, V
  • Prostate Pathology of genetically engineered mice: definitions and classification. The consensus report from the bar harbor meeting of the mouse models of human cancer consortium prostate pathology commitee
    Shappel, SB; Thomas, GV; Roberts, RL; Herbert, R; Ittmann, MM; Rubin, MA; Humphrey, PA; Sundberg, JP; Rozengurt, N; Barrios, R; Ward, JM; Cardiff, RD
  • Melatonin slowed the early biochemical progression of hormone‐refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype
    Shiu, SYW; Law, IC; Lau, KW; Tam, PC; Yip, AWC; Ng, WT
  • Melatonin MT1 receptor‐induced transcriptional up‐regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B (NF‐κB): potential implications on prostate cancer chemoprevention
    Shiu, SYW; Leung, WY; Tam, CW; Liu, VWS; Yao, KM
  • Melatonin and prostate cancer cell proliferation: interplay with castration, epidermal growth factor, and androgen sensitivity
    Siu, SWF; Lau, KW; Tam, PC; Shiu, SYW
  • Oxidative stress and cancer: an overview
    Sosa, V; Moliné, T; Somoza, R; Paciucci, R; Kondoh, H; Leon, L
  • Oxidative stress and disease
    Spector, A
  • Stereological changes in rat ventral prostate induced by melatonin
    Srivilai, W; Withyachumnarnkul, B; Trakulrungsi, W
  • The expression of drug resistance gene products during the progression of human prostate cancer
    Sullivan, GF; Amenta, PS; Villanueva, JD; Alvarez, CJ; Yang, JM; Hait, WN
  • Effects of streptozotocin (STZ)‐induced diabetes and insulin replacement on rat ventral prostate
    Suthagar, E; Soudamani, S; Yuvaraj, S; Ismail Khan, A; Aruldhas, MM; Balasubramanian, K
  • Functional interplay between melatonin receptor‐mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer
    Tam, CW; Shiu, SYW
  • Diabetes and cancer: epidemiological, clinical, and experimental perspectives
    Tseng, CH; Chen, CJ; Landolph, JR
  • Fiber reorganization in the rat ventral prostate following androgen deprivation: a possible role for smooth muscle cells
    Vilamaior, PSL; Felisbino, SL; Taboga, SR; Carvalho, HF
  • Oxidative stress in the pathogenesis of diabetic neuropathy
    Vincent, AM; Russell, JW; Low, P; Feldman, EL
  • Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats
    Vural, H; Sabuncu, T; Arslan, SO; Aksoy, N
  • Cell differentiation lineage in the prostate
    Wang, Y; Hayward, S; Cao, M; Thayer, K; Cunha, G
  • Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
    Wautier, MP; Chappey, O; Corda, S; Stern, DM; Schmidt, AM; Wautier, JL
  • Principles and methods for the morphometric study of the lung and other organs
    Weibel, ER
  • Streptozocin: a review of its pharmacology, efficacy, and toxicity
    Weiss, RB
  • Daily melatonin administration to middle‐aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat
    Wolden‐Hanson, T; Mitton, DR; Mccants, RL; Yellon, SM; Wilkinson, CW; Matsumoto, AM; Rasmussen, DD
  • Potential involvement of mt1 receptor and attenuated sex steroid‐induced calcium influx in the direct anti‐proliferative action of melatonin on androgen‐responsive LNCaP human prostate cancer cells
    Xi, SC; Tam, PC; Brown, GM
  • Inhibition of androgen‐sensitive LNCaP prostate cancer growth in vivo by melatonin: association of antiproliferative action of the pineal hormone with mt1 receptor protein expression
    Xi, SC; Siu, SWF; Fong, SW; Shiu, SYW
  • Diabetes mellitus and prostate cancer risk of different grade or stage: a systematic review and meta‐analysis
    Xu, H; Jiang, H; Ding, G; Zhang, H; Zhang, L; Mao, S; Ding, Q
  • Effects of melatonin on reproductive and accessory reproductive organs in male rats
    Yamada, K
  • Enhanced cellular oxidant stress by interaction of advanced glycation end products with their receptors/binding proteins
    Yan, SD; Schmidt, AM; Anderson, GM; Zhang, J; Brett, J; Zou, YS; Pinsky, D; Stern, D
  • Impact of oxidative stress biomarkers and carboxymethyllysine (an advanced glycation end product) on prostate cancer: a prospective study
    Yang, S; Pinney, SM; Mallick, P; Ho, SM; Bracken, B; Wu, T
  • Melatonin inhibits testosterone secretion by acting at hypothalamo‐pituitary‐gonadal axis in the rat
    Yilmaz, B; Kutlu, S; Mogulkoç, R; Canpolat, S; Sandal, S; Tarakçi, B; Kelestimur, H
  • An assessment of the shared allelic architecture between type 2 diabetes and prostate cancer
    Yu, OH; Foulkes, WD; Dastani, Z; Martin, RM; Eeles, R; Richards, JB
  • Global DNA hypomethylation in prostate cancer development and progression: a systematicreview
    Zelic, R; Fiano, V; Grasso, C; Zugna, D; Pettersson, A; Gillio‐Tos, A; Merletti, F; Richiardi, L

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