179 patients suspected of cosmetic allergy were patch tested with a series of 16 fragrance materials and 9 preservatives. In 67 patients (37.4%), for more of these substances gave positive reactions. In the group of fragrance materials, the largest numbers of positive patch test reactions were seen to isocugenol, oak moss, geraniol, α‐amylcinnamic alcohol, and a mixture of α‐amylcinnamic aldehyde and α‐hexylcinnamic aldehyde. The fragrance mix in the ICDRG standard series detected nearly 80% of cases of contact allergy to fragrance materials other than its constituents. In the group of preservatives, Kathon CG® and quaternium‐15 scored the highest number of positive reactions. Its is argued that the commonly used patch test concentrate on of 2% for oak moss and geraniol may be too low to detect all cases of sensitization.
Contact Dermatitis – Wiley
Published: Feb 1, 1985
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