Abbreviations ALL acute lymphoblastic leukemia B19 human parvovirus B19 BMT bone marrow transplantation CMV cytomegalovirus CsA cyclosporin A EBV Epstein–Barr virus HHV human herpesvirus HIV human immunodeficiency virus HSV herpes simplex virus IgG immunoglobulin G IgM immunoglobulin M ITP idiopathic thrombocytopenic purpura IVIG intravenous immunoglobulin PCR polymerase chain reaction RSV respiratory syncytial virus Tx transplantation VZV varicella zoster virus. Transplant recipients are known to be susceptible to primary viral infections and to re‐activation of persistent virus. Most of the clinically relevant infections are caused by the herpesviridae group (CMV, EBV, VZV, HSV I/II, HHV IV), respiratory viruses (RSV, parainfluenza virus 1–3, influenza A and B viruses, adenoviruses, and rhinoviruses), and hepatitis B and C. Despite improvements in the management of patients, infections following Tx remain significant causes of morbidity and mortality. Viral infections in transplant recipients are usually described in a time‐dependent manner, as predisposing risk factors are different at different stages after Tx. The incidence and outcome of the infection is also highly dependent on the different degree of immunosuppression following organ and bone marrow Txs, respectively. Furthermore, lack of pre‐existing immunity to certain infections, together with a more immature immune system, make young children at especially
Pediatric Transplantation – Wiley
Published: Oct 1, 2001
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