Parental obesity and overweight affect the body‐fat accumulation in the offspring: the possible effect of a high‐fat diet through epigenetic inheritance

Parental obesity and overweight affect the body‐fat accumulation in the offspring: the possible... The prevalence of obesity in adults has been rising continually, as has the prevalence of childhood obesity, and a large number of epidemiological studies have demonstrated a direct relationship between parental obesity and childhood obesity. In this paper, we review the effect of diet, the intrauterine environment, and the genetic inheritance on obesity. We described a study in detail that used experimental animals as a model to investigate the effect of a parental high‐fat diet on body‐fat accumulation in their offspring. Fertilized eggs were transplanted in that study, and body‐fat accumulation in the offspring of the parents fed a high‐fat diet was found to be greater than in the offspring of the parents fed a low‐fat diet, even when the experimental conditions were the same in the intrauterine and subsequent environment. The results suggested that a parental high‐fat diet before intrauterine developmental stage may increase body‐fat accumulation in the offspring. We discuss the possibility that parental diet may influence the lifelong health of offspring and epigenetic inheritance may be occurred. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obesity Reviews Wiley

Parental obesity and overweight affect the body‐fat accumulation in the offspring: the possible effect of a high‐fat diet through epigenetic inheritance

Obesity Reviews, Volume 7 (2) – May 1, 2006

Loading next page...
 
/lp/wiley/parental-obesity-and-overweight-affect-the-body-fat-accumulation-in-GuHdqutUXp
Publisher
Wiley
Copyright
"Copyright © 2006 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
1467-7881
eISSN
1467-789X
D.O.I.
10.1111/j.1467-789X.2006.00232.x
Publisher site
See Article on Publisher Site

Abstract

The prevalence of obesity in adults has been rising continually, as has the prevalence of childhood obesity, and a large number of epidemiological studies have demonstrated a direct relationship between parental obesity and childhood obesity. In this paper, we review the effect of diet, the intrauterine environment, and the genetic inheritance on obesity. We described a study in detail that used experimental animals as a model to investigate the effect of a parental high‐fat diet on body‐fat accumulation in their offspring. Fertilized eggs were transplanted in that study, and body‐fat accumulation in the offspring of the parents fed a high‐fat diet was found to be greater than in the offspring of the parents fed a low‐fat diet, even when the experimental conditions were the same in the intrauterine and subsequent environment. The results suggested that a parental high‐fat diet before intrauterine developmental stage may increase body‐fat accumulation in the offspring. We discuss the possibility that parental diet may influence the lifelong health of offspring and epigenetic inheritance may be occurred.

Journal

Obesity ReviewsWiley

Published: May 1, 2006

Keywords: ; ; ;

References

  • Obesity in children and young people: a crisis in public health
    Lobstein, T; Baur, L; Uauy, R
  • Comment: the global epidemic of childhood obesity: is there a role for the paediatrician?
    Stettler, N
  • Preventive strategies against weight gain and obesity
    Swinburn, B; Egger, G
  • Fat and energy balance
    Pagliassotti, MJ; Gayles, EC; Hill, JO
  • Role of the prenatal environment in the development of obesity
    Whitaker, RC; Dietz, WH
  • Increased fetal adiposity: a very sensitive marker of abnormal in utero development
    Catalano, PM; Thomas, A; Huston‐Presley, L; Amini, SB
  • Role of candidate genes in the responses to long‐term overfeeding: review of findings
    Ukkola, O; Bouchard, C
  • Obesity – is it a genetic disorder?
    Loos, RJ; Bouchard, C
  • Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort
    Ukkola, O; Ravussin, E; Jacobson, P; Sjostrom, L; Bouchard, C
  • Glucose‐induced norepinephrine levels and obesity resistance
    Levin, BE; Sullivan, AC
  • Epigenetic germline inheritance
    Chong, S; Whitelaw, E
  • Blood S‐adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy
    Poirier, LA; Brown, AT; Fink, LM; Wise, CK; Randolph, CJ; Delongchamp, RR; Fonseca, VA

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off