Correspondence Clinical Letter intravascular accentuation as well as leukocytoclasia, mucin Clinical Letter deposits, and areas of necrosis (Figure 2a, b). Immunost- Paraneoplastic pyoderma gangrenosum-like aining showed intravascular accumulation of CD8+ T cells predominantly negative for the proliferation marker Ki67 ulceration in T-cell large granular lymphocytic (Figure 2c–e). Said findings led to the suspected diagnosis leukemia of a leukemic T-cell lymphoma variant with a cytotoxic im- munophenotype. Further diagnostic workup revealed peripheral leukope- DOI: 10.1111/ddg.13405 nia (3.64/nL, normal range 4–10/nL) accompanied by marked relative lymphocytosis (74 %, normal range 25–40 %), neut- Dear Editors, ropenia (4 %, normal range 50–70 %), increased antinuclear antibody levels (1 : 2,560), and splenomegaly (craniocaudal We present a case of pyoderma gangrenosum-like ulcerati- diameter 14.7 cm). Flow cytometric immunophenotyping on associated with weight loss and fatigue as first indication of peripheral blood indicated a large clonal cell population of T-cell large granular lymphocytic (T-LGL) leukemia. A (CD3+/ CD4–/ CD8+/ CD5+ / CD7–) that accounted for low 66-year-old woman was referred to our outpatient clinic for 68 % of lymphocytes and 22 % of all nuclear peripheral blood evaluation of a suspected insect bite with ecthyma formati- cells. Bone marrow biopsy showed interstitial lymphocytosis on.
Journal Der Deutschen Dermatologischen Gesellschaft – Wiley
Published: Jan 1, 2018
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