Paraneoplastic pyoderma gangrenosum‐like ulceration in T‐cell large granular lymphocytic leukemia

Paraneoplastic pyoderma gangrenosum‐like ulceration in T‐cell large granular lymphocytic... Correspondence Clinical Letter intravascular accentuation as well as leukocytoclasia, mucin Clinical Letter deposits, and areas of necrosis (Figure 2a, b). Immunost- Paraneoplastic pyoderma gangrenosum-like aining showed intravascular accumulation of CD8+ T cells predominantly negative for the proliferation marker Ki67 ulceration in T-cell large granular lymphocytic (Figure 2c–e). Said findings led to the suspected diagnosis leukemia of a leukemic T-cell lymphoma variant with a cytotoxic im- munophenotype. Further diagnostic workup revealed peripheral leukope- DOI: 10.1111/ddg.13405 nia (3.64/nL, normal range 4–10/nL) accompanied by marked relative lymphocytosis (74 %, normal range 25–40 %), neut- Dear Editors, ropenia (4 %, normal range 50–70 %), increased antinuclear antibody levels (1 : 2,560), and splenomegaly (craniocaudal We present a case of pyoderma gangrenosum-like ulcerati- diameter 14.7 cm). Flow cytometric immunophenotyping on associated with weight loss and fatigue as first indication of peripheral blood indicated a large clonal cell population of T-cell large granular lymphocytic (T-LGL) leukemia. A (CD3+/ CD4–/ CD8+/ CD5+ / CD7–) that accounted for low 66-year-old woman was referred to our outpatient clinic for 68 % of lymphocytes and 22 % of all nuclear peripheral blood evaluation of a suspected insect bite with ecthyma formati- cells. Bone marrow biopsy showed interstitial lymphocytosis on. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal Der Deutschen Dermatologischen Gesellschaft Wiley

Paraneoplastic pyoderma gangrenosum‐like ulceration in T‐cell large granular lymphocytic leukemia

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Publisher
Wiley
Copyright
© 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.
ISSN
1610-0379
eISSN
1610-0387
D.O.I.
10.1111/ddg.13405
Publisher site
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Abstract

Correspondence Clinical Letter intravascular accentuation as well as leukocytoclasia, mucin Clinical Letter deposits, and areas of necrosis (Figure 2a, b). Immunost- Paraneoplastic pyoderma gangrenosum-like aining showed intravascular accumulation of CD8+ T cells predominantly negative for the proliferation marker Ki67 ulceration in T-cell large granular lymphocytic (Figure 2c–e). Said findings led to the suspected diagnosis leukemia of a leukemic T-cell lymphoma variant with a cytotoxic im- munophenotype. Further diagnostic workup revealed peripheral leukope- DOI: 10.1111/ddg.13405 nia (3.64/nL, normal range 4–10/nL) accompanied by marked relative lymphocytosis (74 %, normal range 25–40 %), neut- Dear Editors, ropenia (4 %, normal range 50–70 %), increased antinuclear antibody levels (1 : 2,560), and splenomegaly (craniocaudal We present a case of pyoderma gangrenosum-like ulcerati- diameter 14.7 cm). Flow cytometric immunophenotyping on associated with weight loss and fatigue as first indication of peripheral blood indicated a large clonal cell population of T-cell large granular lymphocytic (T-LGL) leukemia. A (CD3+/ CD4–/ CD8+/ CD5+ / CD7–) that accounted for low 66-year-old woman was referred to our outpatient clinic for 68 % of lymphocytes and 22 % of all nuclear peripheral blood evaluation of a suspected insect bite with ecthyma formati- cells. Bone marrow biopsy showed interstitial lymphocytosis on.

Journal

Journal Der Deutschen Dermatologischen GesellschaftWiley

Published: Jan 1, 2018

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