Acta Neurol Scand. 2018;138:93–98. wileyonlinelibrary.com/journal/ane
© 2018 John Wiley & Sons A/S.
Published by John Wiley & Sons Ltd
1 | INTRODUCTION
Migraine is a common disorder in working aged population, and the
occurrence peaks in the late teens and around 50 years of age.
sociodemographic correlates have been stable for over 50 years,
and across studies, the estimates of the 12- month prevalence yield
a total of 18.5%.
Pathophysiology of migraine is complex,
matory mechanisms and both peripheral and central sensitization.
Migraine is among the rare neurological conditions accompanying
The reported comorbidity is high and associates with
anxiety, depression, and insomnia.
Pathophysiology linking these
painful disorders remains poorly understood; suggested mecha-
nisms include involvement of peripheral and central sensitization
Neural sensitization has also been shown in other
comorbid painful conditions in migraine, such as rheumatoid arthritis
(RA) and osteoarthritis (OA).
The aim of our study was to evaluate the occurrence and risk of
some comorbid and common painful musculoskeletal disorders such
as fibromyalgia, osteoarthrosis, sciatic syndrome, rheumatoid arthri-
tis and depression among migraineurs in a working aged population
in Finland. The aim is relevant as depression, and the pain conditions
under study are reported to be common disabling conditions in the
Accepted: 19 February 2018
Painful musculosceletal disorders and depression among
working aged migraineurs
| K. Mattila
| M. Sumanen
University of Tampere, Tampere, Finland
University Hospital of Tampere, Tampere,
M.-L. Sumelahti, Faculty of Medicine and
Life Sciences, University of Tampere,
Objective: Musculoskeletal disorders and depression are common among mi-
graineurs. The aim of our study was to evaluate the occurrence of these disorders
among working aged migraineurs.
Material and Methods: The risk for fibromyalgia, rheumatoid arthritis (RA), osteoar-
throsis (OA), sciatic syndrome, and the occurrence of depression was studied among
cases who reported about these conditions and migraine in working aged Finnish
population in The Health and Social Support Study (HeSSup) based on postal ques-
tionnaire in 2012. Group differences were tested by chi- square test. Odds ratios
(ORs with 95% CI) adjusted for age, gender, education level and depression were
calculated with logistic regression analysis.
Results: Total of 1505 migraineurs (13%) and 8092 controls were included among the
11 596 responders in 2012. Age and gender adjusted ORs, 2.37 (95% CI 1.81- 3.09)
for fibromyalgia, 1.46 (1.10- 1.95) for RA, 1.58 (1.38- 1.80) for OA, and 2.09 (1.84-
2.37) for sciatic syndrome, were significant. At least moderate depression was more
common among migraineurs (7.3%) than among controls (3.4%) (P < .001).
Conclusion: Recognition of comorbid musculoskeletal disorders and mood disorders
among migraineurs needs targeted outreach in working aged population. The acute
and preventive treatments to control for neuronal sensitization in migraine and co-
morbid pain disorders may benefit of individual treatment plan and tailored use of
comorbidity, fibromyalgia, migraine, musculoskeletal disorders