Otx1 and Otx2 in the development and evolution of the mammalian brain

Otx1 and Otx2 in the development and evolution of the mammalian brain In the last decade, a number of genes related to the induction, specification and regionalization of the brain were isolated and their functional properties currently are being dissected. Among these, Otx1 and Otx2 play a pivotal role in several processes of brain morphogenesis. Findings from several groups now confirm the importance of Otx2 in the early specification of neuroectoderm destined to become fore–midbrain, the existence of an Otx gene dosage‐dependent mechanism in patterning the developing brain, and the involvement of Otx1 in corticogenesis. Some of these properties appear particularly fascinating when considered in evolutionary terms and highlight the central role of Otx genes in the establishment of the genetic program defining the complexity of a vertebrate brain. This review deals with the major aspects related to the roles played by Otx1 and Otx2 in the development and evolution of the mammalian brain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The EMBO Journal Wiley

Otx1 and Otx2 in the development and evolution of the mammalian brain

The EMBO Journal, Volume 17 (23) – Jan 1, 1998

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Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc
ISSN
0261-4189
eISSN
1460-2075
DOI
10.1093/emboj/17.23.6790
Publisher site
See Article on Publisher Site

Abstract

In the last decade, a number of genes related to the induction, specification and regionalization of the brain were isolated and their functional properties currently are being dissected. Among these, Otx1 and Otx2 play a pivotal role in several processes of brain morphogenesis. Findings from several groups now confirm the importance of Otx2 in the early specification of neuroectoderm destined to become fore–midbrain, the existence of an Otx gene dosage‐dependent mechanism in patterning the developing brain, and the involvement of Otx1 in corticogenesis. Some of these properties appear particularly fascinating when considered in evolutionary terms and highlight the central role of Otx genes in the establishment of the genetic program defining the complexity of a vertebrate brain. This review deals with the major aspects related to the roles played by Otx1 and Otx2 in the development and evolution of the mammalian brain.

Journal

The EMBO JournalWiley

Published: Jan 1, 1998

Keywords: ; ; ; ;

References

  • Retinoic acid induces stage‐specific repatterning of the rostral central nervous system
    Avantaggiato, V; Acampora, D; Tuorto, F; Simeone, A
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    Bally‐Cuif, L; Wassef, M
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    Bouwmeester, T; Leyns, L
  • Pax‐6 in development and evolution
    Callaerts, P; Halder, G; Gehring, WJ
  • Constructing the cerebral cortex: neurogenesis and fate determination
    McConnell, SK
  • The embryonic vertebrate forebrain: the prosomeric model
    Rubenstein, JLR; Martinez, S; Shimamura, K; Puelles, L
  • Mesoderm induction and development of the embryonic axis in amniotes
    Stern, CD
  • Mouse gastrulation: the formation of a mammalian body plan
    Tam, PPL; Behringer, RR
  • Molecular evidence for deep precambrian divergences among metazoan phyla
    Wray, GA; Levinton, JS; Shapiro, LH

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