Osteogenic efficacy of BMP‐2 mixed with hydrogel and bone substitute in peri‐implant dehiscence defects in dogs: 16 weeks of healing

Osteogenic efficacy of BMP‐2 mixed with hydrogel and bone substitute in peri‐implant... INTRODUCTIONDehiscence‐type defects are frequently encountered at the coronal part of an implant placed in a narrow alveolar ridge. The long‐term success of implant therapy requires that the implant surface be surrounded by vital osseous tissue that is sufficiently thick to support the occlusal load (Glauser et al., ). The concept of guided bone regeneration (GBR) has been introduced for building osseous tissue around an implant (Hammerle, Jung & Feloutzis, ; Hammerle, Schmid, Olah & Lang, ). A barrier membrane for excluding unwanted soft tissue and bone grafting material for space creation are key components in the GBR procedure. However, it is difficult to manipulate and customize the sheet‐like barrier membrane to fit the variable shape of a defect during the surgical procedure. In addition, a high prevalence of membrane exposure is associated with poor clinical outcomes (Machtei, ).Various membrane alternatives have been used for GBR in attempts to overcome these shortcomings. Among them, the barrier function and easy manageability of injectable polyethylene glycol (PEG) hydrogel have been demonstrated in a large number of clinical and preclinical studies (Jung, Lecloux et al., ; Jung, Halg, Thoma & Hammerle, ; Jung et al., ). A recent preclinical study found no significant difference in new http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Oral Implants Research Wiley

Osteogenic efficacy of BMP‐2 mixed with hydrogel and bone substitute in peri‐implant dehiscence defects in dogs: 16 weeks of healing

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
0905-7161
eISSN
1600-0501
D.O.I.
10.1111/clr.13117
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONDehiscence‐type defects are frequently encountered at the coronal part of an implant placed in a narrow alveolar ridge. The long‐term success of implant therapy requires that the implant surface be surrounded by vital osseous tissue that is sufficiently thick to support the occlusal load (Glauser et al., ). The concept of guided bone regeneration (GBR) has been introduced for building osseous tissue around an implant (Hammerle, Jung & Feloutzis, ; Hammerle, Schmid, Olah & Lang, ). A barrier membrane for excluding unwanted soft tissue and bone grafting material for space creation are key components in the GBR procedure. However, it is difficult to manipulate and customize the sheet‐like barrier membrane to fit the variable shape of a defect during the surgical procedure. In addition, a high prevalence of membrane exposure is associated with poor clinical outcomes (Machtei, ).Various membrane alternatives have been used for GBR in attempts to overcome these shortcomings. Among them, the barrier function and easy manageability of injectable polyethylene glycol (PEG) hydrogel have been demonstrated in a large number of clinical and preclinical studies (Jung, Lecloux et al., ; Jung, Halg, Thoma & Hammerle, ; Jung et al., ). A recent preclinical study found no significant difference in new

Journal

Clinical Oral Implants ResearchWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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