Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification

Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to... IntroductionDedifferentiated liposarcoma (DDLPS) is defined as an atypical lipomatous tumour/well‐differentiated liposarcoma (ALT/WDLPS) that shows progression to a sarcoma of variable histological grade, and the sarcoma component is usually non‐lipogenic and high grade. This WD/DDLPS group liposarcoma is the most common type of soft tissue sarcoma and is characterised by substantial amplification of genes located at 12q13‐15, particularly MDM2, and is accompanied by ring or giant marker chromosomes. It is also widely recognised that DDLPS sometimes exhibits heterologous differentiation. Myogenic differentiation is the most common type, and the impact of myogenic differentiation on prognosis has been investigated. Conversely, formation of bone tissue has been reported in 0.6–29% of cases in large studies of DDLPS, and the bone formation has usually been described as either ‘osteosarcomatous differentiation’ or ‘metaplastic bone formation’ according to histological analyses. Recently, it became known that DDLPS can also show bone formation that is histologically similar to skeletal low‐grade osteosarcoma. However, it remains unclear whether the bone tissue known as ‘metaplastic bone’ is formed by reactive (non‐neoplastic) mesenchymal cells or if this tissue is also produced by tumour cells. In addition, in contrast to myogenic differentiation, the clinical importance of osteogenic differentiation in DDLPS has not been http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Histopathology Wiley

Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons Ltd
ISSN
0309-0167
eISSN
1365-2559
D.O.I.
10.1111/his.13421
Publisher site
See Article on Publisher Site

Abstract

IntroductionDedifferentiated liposarcoma (DDLPS) is defined as an atypical lipomatous tumour/well‐differentiated liposarcoma (ALT/WDLPS) that shows progression to a sarcoma of variable histological grade, and the sarcoma component is usually non‐lipogenic and high grade. This WD/DDLPS group liposarcoma is the most common type of soft tissue sarcoma and is characterised by substantial amplification of genes located at 12q13‐15, particularly MDM2, and is accompanied by ring or giant marker chromosomes. It is also widely recognised that DDLPS sometimes exhibits heterologous differentiation. Myogenic differentiation is the most common type, and the impact of myogenic differentiation on prognosis has been investigated. Conversely, formation of bone tissue has been reported in 0.6–29% of cases in large studies of DDLPS, and the bone formation has usually been described as either ‘osteosarcomatous differentiation’ or ‘metaplastic bone formation’ according to histological analyses. Recently, it became known that DDLPS can also show bone formation that is histologically similar to skeletal low‐grade osteosarcoma. However, it remains unclear whether the bone tissue known as ‘metaplastic bone’ is formed by reactive (non‐neoplastic) mesenchymal cells or if this tissue is also produced by tumour cells. In addition, in contrast to myogenic differentiation, the clinical importance of osteogenic differentiation in DDLPS has not been

Journal

HistopathologyWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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