IntroductionDedifferentiated liposarcoma (DDLPS) is defined as an atypical lipomatous tumour/well‐differentiated liposarcoma (ALT/WDLPS) that shows progression to a sarcoma of variable histological grade, and the sarcoma component is usually non‐lipogenic and high grade. This WD/DDLPS group liposarcoma is the most common type of soft tissue sarcoma and is characterised by substantial amplification of genes located at 12q13‐15, particularly MDM2, and is accompanied by ring or giant marker chromosomes. It is also widely recognised that DDLPS sometimes exhibits heterologous differentiation. Myogenic differentiation is the most common type, and the impact of myogenic differentiation on prognosis has been investigated. Conversely, formation of bone tissue has been reported in 0.6–29% of cases in large studies of DDLPS, and the bone formation has usually been described as either ‘osteosarcomatous differentiation’ or ‘metaplastic bone formation’ according to histological analyses. Recently, it became known that DDLPS can also show bone formation that is histologically similar to skeletal low‐grade osteosarcoma. However, it remains unclear whether the bone tissue known as ‘metaplastic bone’ is formed by reactive (non‐neoplastic) mesenchymal cells or if this tissue is also produced by tumour cells. In addition, in contrast to myogenic differentiation, the clinical importance of osteogenic differentiation in DDLPS has not been
Histopathology – Wiley
Published: Jan 1, 2018
Keywords: ; ;
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