Osimertinib for an older de novo T790M patient with chronic kidney disease

Osimertinib for an older de novo T790M patient with chronic kidney disease Dear Editor,Osimertinib yielded significantly greater efficacy than did platinum therapy plus pemetrexed in patients with T790M‐positive advanced non‐small cell lung cancer (NSCLC; including those with central nervous system metastases) in whom the disease had progressed during first‐line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKI) therapy. Just 5% of the patients discontinued osimertinib owing to an adverse effect. Among the reported deaths, the only death possibly related to treatment as reported by the investigator was as a result of interstitial lung disease. An improvement or stability of the lung cancer symptoms and functioning domains of quality of life was observed with osimertinib. Owing to the increase in the incidence of lung cancer among older individuals, the efficacy and safety of EGFR‐TKI for the treatment of older patients with NSCLC have recently garnered interest. Aging is associated with poor performance status. As osimertinib has finally been approved for clinical use, rebiopsies are often required in lung cancer patients who are positive for EGFR mutations and currently undergoing treatment.In this report, we present an advanced NSCLC patient who was unsuitable for chemotherapy because of chronic kidney disease (CKD) as a result of diabetes mellitus, and therefore was started on osimertinib at http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Geriatrics & Gerontology International Wiley

Osimertinib for an older de novo T790M patient with chronic kidney disease

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Japan Geriatrics Society
ISSN
1444-1586
eISSN
1447-0594
D.O.I.
10.1111/ggi.13230
Publisher site
See Article on Publisher Site

Abstract

Dear Editor,Osimertinib yielded significantly greater efficacy than did platinum therapy plus pemetrexed in patients with T790M‐positive advanced non‐small cell lung cancer (NSCLC; including those with central nervous system metastases) in whom the disease had progressed during first‐line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKI) therapy. Just 5% of the patients discontinued osimertinib owing to an adverse effect. Among the reported deaths, the only death possibly related to treatment as reported by the investigator was as a result of interstitial lung disease. An improvement or stability of the lung cancer symptoms and functioning domains of quality of life was observed with osimertinib. Owing to the increase in the incidence of lung cancer among older individuals, the efficacy and safety of EGFR‐TKI for the treatment of older patients with NSCLC have recently garnered interest. Aging is associated with poor performance status. As osimertinib has finally been approved for clinical use, rebiopsies are often required in lung cancer patients who are positive for EGFR mutations and currently undergoing treatment.In this report, we present an advanced NSCLC patient who was unsuitable for chemotherapy because of chronic kidney disease (CKD) as a result of diabetes mellitus, and therefore was started on osimertinib at

Journal

Geriatrics & Gerontology InternationalWiley

Published: Jan 1, 2018

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