ORMDL3 and its implication in inflammatory disorders

ORMDL3 and its implication in inflammatory disorders A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini‐review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Rheumatic Diseases Wiley
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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
International Journal of Rheumatic Diseases © 2018 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
ISSN
1756-1841
eISSN
1756-185X
D.O.I.
10.1111/1756-185X.13324
Publisher site
See Article on Publisher Site

Abstract

A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini‐review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders.

Journal

International Journal of Rheumatic DiseasesWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ;

References

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