Periodontology 2000, Vol. 23, 2000, 110–120 Co py rig ht C Mu nk sga ard 2 0 0 0 Printed in Denmark Á All rights reserved PER IODON TOLOG Y 2000 ISSN 0906-6713 Oral disease, cardiovascular disease and systemic inﬂammation J AMES D. B ECK, G ARY S LADE &S TEVEN O FFENBACHER Atherosclerosis has been deﬁned as a progressive to occur in persons who are older, male, of lower disease process that involves the large to medium educational status, have fewer ﬁnancial resources, sized muscular and the large elastic arteries. Athero- who smoke, are stressed, and are socially isolated. sclerosis can lead to coronary heart disease, as well These commonalties hint that periodontal diseases as myocardial and cerebral infarctions. Periodontitis and heart disease may share a similar causative is an inﬂammatory reaction (to gram-negative, an- pathway. aerobic bacterial infections) of the supportive tissues surrounding the tooth, including the periodontal ligament, cementum, and alveolar and supporting Associations between periodontal bone. disease and atherosclerosis and World Health Organization statistics indicate that in 1995, cardiovascular diseases were responsible for coronary heart disease 20% of deaths worldwide, numbering 14 million people. In developed countries, cardiovascular dis- A number of studies in the
Periodontology 2000 – Wiley
Published: Jun 1, 2000
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