Ontogeny of Dopamine D1 Receptors in Rat Striatum

Ontogeny of Dopamine D1 Receptors in Rat Striatum The development of dopamine D1 receptors in rat striatum during the early postnatal period is described, using (3H)piflutixol as ligand. Dopamine D1 receptors increase in number from day of birth until about 21 days of age, when they reach adult levels. This increase in number parallels the increase in several other dopamine markers in striatum during the same time period. The increase is reflected in an increase in Bmax of ligand binding to D1 receptors. All other properties of D1 receptors that were examined do not change throughout this developmental period and are essentially the same as those found in adult tissue. These include association and dissociation rates, affinity for piflutixol as determined by kinetic and saturation studies, and pharmacology. These studies provide a biochemical and pharmacological basis for further studies on the ontogeny of dopamine receptors and of striatum and on factors regulating development of this region. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

Ontogeny of Dopamine D1 Receptors in Rat Striatum

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Publisher
Wiley
Copyright
Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1988.tb02992.x
Publisher site
See Article on Publisher Site

Abstract

The development of dopamine D1 receptors in rat striatum during the early postnatal period is described, using (3H)piflutixol as ligand. Dopamine D1 receptors increase in number from day of birth until about 21 days of age, when they reach adult levels. This increase in number parallels the increase in several other dopamine markers in striatum during the same time period. The increase is reflected in an increase in Bmax of ligand binding to D1 receptors. All other properties of D1 receptors that were examined do not change throughout this developmental period and are essentially the same as those found in adult tissue. These include association and dissociation rates, affinity for piflutixol as determined by kinetic and saturation studies, and pharmacology. These studies provide a biochemical and pharmacological basis for further studies on the ontogeny of dopamine receptors and of striatum and on factors regulating development of this region.

Journal

Journal of NeurochemistryWiley

Published: Mar 1, 1988

References

  • Tyrosine hydroxylase in rat brain: developmental characteristics
    Coyle, Coyle; Axelrod, Axelrod
  • Multiple receptors for dopamine
    Kebabian, Kebabian; Calne, Calne
  • ( 3 H)Fluphenazine binding to brain membranes: simultaneous measurement of D‐1 and D‐2 receptor sites
    Morgan, Morgan; Finch, Finch
  • The attraction of proteins for small molecules and ions
    Scatchard, Scatchard
  • Ontogeny of dopamine D1 receptors in rat striatum
    Zeng, Zeng; Hyttel, Hyttel; Murrin, Murrin

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