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E. Cherubinim, R. North, A. Surprenant (1984)
Quinine blocks a calcium‐activated potassium conductance in mammalian enteric neuronesBritish Journal of Pharmacology, 83
R. North, M. Yoshimura (1984)
The actions of noradrenaline on neurones of the rat substantia gelatinosa in vitro.The Journal of Physiology, 349
K. Morita, R. North, T. Tokimasa (1982)
The calcium‐activated potassium conductance in guinea‐pig myenteric neuronesThe Journal of Physiology, 329
(1983)
Substantia gelatinosa neurones in vitro hyperpolarized by enkephalin
(1981)
Forskolin : unique diterpene activator of adenylate cyclase in neuroblastoma glioma hybrid cells
J. Korf, B. Bunney, G. Aghajanian (1974)
Noradrenergic neurons: morphine inhibition of spontaneous activity.European journal of pharmacology, 25 2
(1985)
Characterization of a2-adrenoceptors
R. North, T. Tokimasa (1984)
The time course of muscarinic depolarization of guinea‐pig myenteric neuronesBritish Journal of Pharmacology, 82
A. Marty (1983)
Ca2+-dependent K+ channels with large unitary conductanceTrends in Neurosciences, 6
R. North, A. Surprenant (1985)
Inhibitory synaptic potentials resulting from alpha 2‐adrenoceptor activation in guinea‐pig submucous plexus neurones.The Journal of Physiology, 358
John Williams, T. Egan, R. North (1982)
Enkephalin opens potassium channels on mammalian central neuronesNature, 299
John Williams, Graeme Henderson, R. North (1985)
Characterization of α2-adrenoceptors which increase potassium conductance in rat locus coeruleus neuronesNeuroscience, 14
John Williams, R. North, S. Shefner, S. Nishi, T. Egan (1984)
Membrane properties of rat locus coeruleus neuronesNeuroscience, 13
T. Egan, G. Henderson, R. North, J. Williams (1983)
Noradrenaline‐mediated synaptic inhibition in rat locus coeruleus neurones.The Journal of Physiology, 345
E. Cherubini, R. North
, u and K opioids inhibit transmitter release by different mechanisms
H. Higashi, K. Morita, R. North (1984)
Calcium‐dependent after‐potentials in visceral afferent neurones of the rabbit.The Journal of Physiology, 355
(1984)
A patch - clamp study of potassium channels and whole cell currents of the mouse lacrimal gland
R. North, J. Williams (1983)
Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neuronesBritish Journal of Pharmacology, 80
(1984)
Dynorphin reduces voltage - dependent calcium conductance of sensory neurones : a voltage clamp study
P. Nemeth, D. Zafirov, J. Wood (1984)
Forskolin mimics slow synaptic excitation in myenteric neurons.European journal of pharmacology, 101 3-4
R. Adrian (1964)
The rubidium and potassium permeability of frog muscle membraneThe Journal of Physiology, 175
J. Cedarbaum, G. Aghajanian (1977)
Catecholamine receptors on locus coeruleus neurons: pharmacological characterization.European journal of pharmacology, 44 4
M. Hanani, C. Shaw (1977)
A potassium contribution to the response of the barnacle photoreceptor.The Journal of Physiology, 270
G. Burgess, M. Claret, D. Jenkinson (1981)
Effects of quinine and apamin on the calcium‐dependent potassium permeability of mammalian hepatocytes and red cells.The Journal of Physiology, 317
C. Pepper, G. Henderson (1980)
Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro.Science, 209 4454
K. Morita, R. North (1982)
Opiate activation of potassium conductance in myenteric neurons: inhibition by calcium ionBrain Research, 242
M. Werz, R. Macdonald (1983)
Opioid peptides selective for mu- and delta-opiate receptors reduce calcium-dependent action potential duration by increasing potassium conductanceNeuroscience Letters, 42
A. Duggan, R. North (1983)
Electrophysiology of opioids.Pharmacological reviews, 35 4
P. Adams, P. Adams, A. Constanti, A. Constanti, David Brown, D. Brown, R. Clark (1982)
Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neuronesNature, 296
Barbara Banks, Christine Brown, G. Burgess, Geoffrey Burnstock, Marc Claret, Thomas Cocks, D. Jenkinson (1979)
Apamin blocks certain neurotransmitter-induced increases in potassium permeabilityNature, 282
S. Bird, M. Kuhar (1977)
Iontophoretic application of opiates to the locus coeruleusBrain Research, 122
John Williams, R. North (1984)
Opiate-receptor interactions on single locus coeruleus neurones.Molecular pharmacology, 26 3
J. Daut (1973)
Modulation of the excitatory synaptic response by fast transient K+ current in snail neurones.Nature: New biology, 246 155
R. West, R. Miller (1983)
Opiates, second messengers and cell response.British medical bulletin, 39 1
G. Aghajanian, C. Vandermaelen (1982)
alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo.Science, 215 4538
(1983)
Dynorphin decreases calcium conductance of mouse cultured dorsal root ganglion neurons
O. Petersen, Y. Maruyama (1984)
Calcium-activated potassium channels and their role in secretionNature, 307
Intracellular recordings were made from locus coeruleus neurones in slices cut from rat pons and superfused in vitro. Membrane currents were recorded with a single‐electrode switch‐clamp amplifier. Opioids, enkephalin analogues or morphine, caused a concentration‐dependent potassium current, which had a maximum value of about 300 pA at ‐60 mV. The opioid‐sensitive potassium conductance was independent of membrane potential between ‐60 and ‐130 mV, but became less as the membrane potential was changed from ‐60 to ‐30 mV. The opioid outward current was reduced by quinine (100 microM‐1 mM) and barium (30 microM‐2 mM), but not by 4‐aminopyridine (100 microM‐1 mM) or tetraethylammonium (10 mM). A potassium current with similar properties flowed for several seconds after a burst of action potentials; this appeared to result from calcium entering the neurone during the action potentials. The alpha 2‐adrenoceptor agonists noradrenaline and clonidine caused a concentration‐dependent potassium conductance increase which had the same maximum value as that caused by opioids in the same neurones. Experiments in which an opioid and an alpha 2‐adrenoceptor agonist were superfused together indicated that the same potassium conductance is increased by both agonists.
The Journal of Physiology – Wiley
Published: Jul 1, 1985
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