Immediate contact allergy to hydrolysed wheat protein (HWP) has frequently been reported in consumers of HWP‐containing cosmetics from Japan and Europe (). We present here the first case of confirmed occupational immediate hypersensitivity to HWP.Case ReportA 34‐year‐old technician, without a medical history, was working in industrial maintenance for a cosmetic manufacturer. He developed two immediate hypersensitivity reactions with a 1‐year interval, 5 min after cleaning a tank containing an anti‐wrinkle cream (Supreme‐DHE™, Ericson, Stockholm, Sweden), despite wearing a protective suit and gloves. The first reaction comprised rhinitis, conjunctivitis, and sneezing, whereas the second episode was more severe, combining immediate contact urticaria, conjunctivitis, and dyspnoea. The patient recovered spontaneously from the first episode, whereas oral glucocorticoid treatment was required for the second. The offending cosmetic product contained 12% Tritisol™ powder, mainly composed of HWP, which represented 10% of the final cosmetic product.The results of open tests remained negative with the cosmetic product and all of the ingredients provided by the manufacturer, including Tritisol™ powder. However, prick tests gave positive results at 20 min (> 50% of the positive control response induced by histamine chloride at 10 mg/ml) for the cosmetic product (10% aq.), Tritisol™ powder (10% aq.), and wheat extract
Contact Dermatitis – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ;
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