Occupational allergic contact dermatitis caused by antibiotics in healthcare workers – relationship with non‐immediate drug eruptions

Occupational allergic contact dermatitis caused by antibiotics in healthcare... Occupational skin diseases, namely allergic contact dermatitis (ACD), are among the most common occupational diseases , although they may be underreported in many countries . Healthcare workers (HCWs) are most frequently affected , with a high prevalence of contact dermatitis, mainly hand eczema, ranging from 17% to 70% . Occupational risk factors include frequent hand washing, prolonged glove use, and exposure to disinfectants and drugs, which all may be responsible for irritant contact dermatitis or ACD , or immediate reactions, such as contact urticaria/protein contact dermatitis . Occupational ACD caused by systemically administered drugs has been occasionally reported in HCWs, mostly caused by systemic antibiotics such as penicillins, cephalosporins, and aminoglycosides, but does not appear to be frequent . We report 4 cases related to the handling of intravenous antibiotics, and discuss the relationships with reactions on systemic exposure to the antibiotics.MethodsWe performed a retrospective analysis of clinical data and patch test results from HCWs patch tested in the Department of Dermatology of Coimbra Hospital and University Centre (CHUC) between 2010 and 2016, and analysed those with positive reactions to systemic antibiotics. All patients were tested with the European baseline series, the preservative and excipient series, and additional series http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Contact Dermatitis Wiley

Occupational allergic contact dermatitis caused by antibiotics in healthcare workers – relationship with non‐immediate drug eruptions

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Publisher
Wiley
Copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0105-1873
eISSN
1600-0536
D.O.I.
10.1111/cod.12960
Publisher site
See Article on Publisher Site

Abstract

Occupational skin diseases, namely allergic contact dermatitis (ACD), are among the most common occupational diseases , although they may be underreported in many countries . Healthcare workers (HCWs) are most frequently affected , with a high prevalence of contact dermatitis, mainly hand eczema, ranging from 17% to 70% . Occupational risk factors include frequent hand washing, prolonged glove use, and exposure to disinfectants and drugs, which all may be responsible for irritant contact dermatitis or ACD , or immediate reactions, such as contact urticaria/protein contact dermatitis . Occupational ACD caused by systemically administered drugs has been occasionally reported in HCWs, mostly caused by systemic antibiotics such as penicillins, cephalosporins, and aminoglycosides, but does not appear to be frequent . We report 4 cases related to the handling of intravenous antibiotics, and discuss the relationships with reactions on systemic exposure to the antibiotics.MethodsWe performed a retrospective analysis of clinical data and patch test results from HCWs patch tested in the Department of Dermatology of Coimbra Hospital and University Centre (CHUC) between 2010 and 2016, and analysed those with positive reactions to systemic antibiotics. All patients were tested with the European baseline series, the preservative and excipient series, and additional series

Journal

Contact DermatitisWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ; ;

References

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