Observations on the Effects of Purine Nucleosides on Red‐Cell Preservation

Observations on the Effects of Purine Nucleosides on Red‐Cell Preservation Medical Research Council's Blood Transjksion Research Unit* WHEN blood is stored at 4 C. the rate of loss of viability of the red cells is quite well corre" lated with the rate of fall in their content of adenosine triphosphate (Rapoport, 1947; Denstedt, 1949). If stored red cells are incubated with adenosine their content of adenosine triphosphate (ATP) can be restored to normal, and their viability considerably improved (Gabrio, Hennessey, Thomasson and Finch, 1955; Gabrio, Donohue and Finch, 1955). Incubation with inosine or guanosine d also restore the ATP content of stored red cells (Gabrio and Huennekens, 1gs5a). The beneficial effect on stored red cells of incubation with adenosine or guanosine was confirmed by Prankerd (1956a). Although inosine appears to be as effective as adenosine in restoring the ATP content of stored red cells (Gabrio and Huennekens, IgSSa), an extensive trial of storage of red cells with inosine has given far less satisfactory results than were obtained in earlier experiments with adenosine (Lange, Crosby, Donohue, Finch, Gibson, McManus and Strimia, 1958). The observations of Dr. T. A. J. Prankerd (personal communication) suggest that only a slight improvement in red-cell preservation is obtained by simply storing red cells at http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Haematology Wiley

Observations on the Effects of Purine Nucleosides on Red‐Cell Preservation

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Publisher
Wiley
Copyright
Copyright © 1959 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0007-1048
eISSN
1365-2141
DOI
10.1111/j.1365-2141.1959.tb04043.x
Publisher site
See Article on Publisher Site

Abstract

Medical Research Council's Blood Transjksion Research Unit* WHEN blood is stored at 4 C. the rate of loss of viability of the red cells is quite well corre" lated with the rate of fall in their content of adenosine triphosphate (Rapoport, 1947; Denstedt, 1949). If stored red cells are incubated with adenosine their content of adenosine triphosphate (ATP) can be restored to normal, and their viability considerably improved (Gabrio, Hennessey, Thomasson and Finch, 1955; Gabrio, Donohue and Finch, 1955). Incubation with inosine or guanosine d also restore the ATP content of stored red cells (Gabrio and Huennekens, 1gs5a). The beneficial effect on stored red cells of incubation with adenosine or guanosine was confirmed by Prankerd (1956a). Although inosine appears to be as effective as adenosine in restoring the ATP content of stored red cells (Gabrio and Huennekens, IgSSa), an extensive trial of storage of red cells with inosine has given far less satisfactory results than were obtained in earlier experiments with adenosine (Lange, Crosby, Donohue, Finch, Gibson, McManus and Strimia, 1958). The observations of Dr. T. A. J. Prankerd (personal communication) suggest that only a slight improvement in red-cell preservation is obtained by simply storing red cells at

Journal

British Journal of HaematologyWiley

Published: Oct 1, 1959

References

  • An animal assay method for the measurement of post‐transfusion survival of stored blood
    Donohue, Donohue; Finch, Finch

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