Obesity reshapes stem cell extracellular vesicles

Obesity reshapes stem cell extracellular vesicles Mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal cells, are capable of differentiation into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. MSCs have shown promise for regenerative cell therapy. For example, adipose‐derived mesenchymal stem cells (ASCs) are widely used in regenerative medicine due to their easy accessibility and abundant quantity. Indeed, ASCs are an attractive cell population for autologous cell therapy given their angiogenic, osteogenic, and immunomodulatory properties. However, the regenerative potential of ASCs isolated from patients may be hindered by the comorbidities such as obesity and metabolic syndrome. It has been shown that ASCs derived from obese animals and humans have reduced proliferative and migratory abilities and an impaired angiogenic capacity whereas they often commit to adipocyte differentiation when compared to those from non‐obese subjects . These findings suggest ASCs from obese subjects have reduced regeneration potential, and more concerning, they may promote the progression of obesity and metabolic disorders. The mechanisms for such changes of ASCs under the obese condition remain elusive.Accumulating evidence indicates that immunoregulatory effects of stem cells via paracrine signaling are as important, if not more so, as their differentiation potential in tissue regeneration . It has been http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytometry Wiley

Obesity reshapes stem cell extracellular vesicles

Loading next page...
 
/lp/wiley/obesity-reshapes-stem-cell-extracellular-vesicles-rB7l6LPrBk
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 International Society for Advancement of Cytometry
ISSN
1552-4922
eISSN
1552-4930
D.O.I.
10.1002/cyto.a.23166
Publisher site
See Article on Publisher Site

Abstract

Mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal cells, are capable of differentiation into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. MSCs have shown promise for regenerative cell therapy. For example, adipose‐derived mesenchymal stem cells (ASCs) are widely used in regenerative medicine due to their easy accessibility and abundant quantity. Indeed, ASCs are an attractive cell population for autologous cell therapy given their angiogenic, osteogenic, and immunomodulatory properties. However, the regenerative potential of ASCs isolated from patients may be hindered by the comorbidities such as obesity and metabolic syndrome. It has been shown that ASCs derived from obese animals and humans have reduced proliferative and migratory abilities and an impaired angiogenic capacity whereas they often commit to adipocyte differentiation when compared to those from non‐obese subjects . These findings suggest ASCs from obese subjects have reduced regeneration potential, and more concerning, they may promote the progression of obesity and metabolic disorders. The mechanisms for such changes of ASCs under the obese condition remain elusive.Accumulating evidence indicates that immunoregulatory effects of stem cells via paracrine signaling are as important, if not more so, as their differentiation potential in tissue regeneration . It has been

Journal

CytometryWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off