Obesity reshapes stem cell extracellular vesicles

Obesity reshapes stem cell extracellular vesicles Mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal cells, are capable of differentiation into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. MSCs have shown promise for regenerative cell therapy. For example, adipose‐derived mesenchymal stem cells (ASCs) are widely used in regenerative medicine due to their easy accessibility and abundant quantity. Indeed, ASCs are an attractive cell population for autologous cell therapy given their angiogenic, osteogenic, and immunomodulatory properties. However, the regenerative potential of ASCs isolated from patients may be hindered by the comorbidities such as obesity and metabolic syndrome. It has been shown that ASCs derived from obese animals and humans have reduced proliferative and migratory abilities and an impaired angiogenic capacity whereas they often commit to adipocyte differentiation when compared to those from non‐obese subjects . These findings suggest ASCs from obese subjects have reduced regeneration potential, and more concerning, they may promote the progression of obesity and metabolic disorders. The mechanisms for such changes of ASCs under the obese condition remain elusive.Accumulating evidence indicates that immunoregulatory effects of stem cells via paracrine signaling are as important, if not more so, as their differentiation potential in tissue regeneration . It has been http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cytometry Wiley

Obesity reshapes stem cell extracellular vesicles

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 International Society for Advancement of Cytometry
ISSN
1552-4922
eISSN
1552-4930
D.O.I.
10.1002/cyto.a.23166
Publisher site
See Article on Publisher Site

Abstract

Mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal cells, are capable of differentiation into a variety of cell types, including osteoblasts, chondrocytes, myocytes, and adipocytes. MSCs have shown promise for regenerative cell therapy. For example, adipose‐derived mesenchymal stem cells (ASCs) are widely used in regenerative medicine due to their easy accessibility and abundant quantity. Indeed, ASCs are an attractive cell population for autologous cell therapy given their angiogenic, osteogenic, and immunomodulatory properties. However, the regenerative potential of ASCs isolated from patients may be hindered by the comorbidities such as obesity and metabolic syndrome. It has been shown that ASCs derived from obese animals and humans have reduced proliferative and migratory abilities and an impaired angiogenic capacity whereas they often commit to adipocyte differentiation when compared to those from non‐obese subjects . These findings suggest ASCs from obese subjects have reduced regeneration potential, and more concerning, they may promote the progression of obesity and metabolic disorders. The mechanisms for such changes of ASCs under the obese condition remain elusive.Accumulating evidence indicates that immunoregulatory effects of stem cells via paracrine signaling are as important, if not more so, as their differentiation potential in tissue regeneration . It has been

Journal

CytometryWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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