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Novel Clinical Observations on Benign Cephalic Histiocytosis in a Large Series

Novel Clinical Observations on Benign Cephalic Histiocytosis in a Large Series Benign cephalic histiocytosis (BCH) is a rare variant of non‐Langerhans cell histiocytosis seen in early childhood and characterized by a widespread eruption of macules and papules mainly on the head and neck, without involvement of acral areas, mucous membranes, and internal organs . All lesions spontaneously resolve in a few years without treatment. Patsatsi et al found in 2014 that there had been only 55 reported cases in the English‐language literature since Gianotti et al first described this disorder in 1971. With a few additional cases thereafter, we presume that there have now been nearly 60 reported cases . We have identified 11 BCH cases over the past 12 years at a single center (Table ), suggesting that the disease may be more common than previously thought. In the present study we aimed to compare the clinical features of these patients with the features of previously presented cases.Clinical and Demographic Characteristics of 11 PatientsCaseAge, MosSexAge at onset, MosLocation of eruptionLesions, nMorphology of lesionsCourse124Female8Face, ears<50Yellow‐brown slightly infiltrated macules and papulesLost to follow‐up224Male6Face, ears, arms, legs<50Reddish slightly infiltrated macules and papulesLost to follow‐up348Male36Face, ears, neck, arms>100Yellow‐pink‐brown slightly infiltrated macules, papulesComplete regression after 2 yrs (no relapse after 9 yrs)472Male9Face, ears, neck, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Dermatology Wiley

Novel Clinical Observations on Benign Cephalic Histiocytosis in a Large Series

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Publisher
Wiley
Copyright
Copyright © 2017 Wiley Periodicals, Inc.
ISSN
0736-8046
eISSN
1525-1470
DOI
10.1111/pde.13153
pmid
28466548
Publisher site
See Article on Publisher Site

Abstract

Benign cephalic histiocytosis (BCH) is a rare variant of non‐Langerhans cell histiocytosis seen in early childhood and characterized by a widespread eruption of macules and papules mainly on the head and neck, without involvement of acral areas, mucous membranes, and internal organs . All lesions spontaneously resolve in a few years without treatment. Patsatsi et al found in 2014 that there had been only 55 reported cases in the English‐language literature since Gianotti et al first described this disorder in 1971. With a few additional cases thereafter, we presume that there have now been nearly 60 reported cases . We have identified 11 BCH cases over the past 12 years at a single center (Table ), suggesting that the disease may be more common than previously thought. In the present study we aimed to compare the clinical features of these patients with the features of previously presented cases.Clinical and Demographic Characteristics of 11 PatientsCaseAge, MosSexAge at onset, MosLocation of eruptionLesions, nMorphology of lesionsCourse124Female8Face, ears<50Yellow‐brown slightly infiltrated macules and papulesLost to follow‐up224Male6Face, ears, arms, legs<50Reddish slightly infiltrated macules and papulesLost to follow‐up348Male36Face, ears, neck, arms>100Yellow‐pink‐brown slightly infiltrated macules, papulesComplete regression after 2 yrs (no relapse after 9 yrs)472Male9Face, ears, neck,

Journal

Pediatric DermatologyWiley

Published: Jul 1, 2017

References